Indwara ya Lymphoblastique ikaze (T-BYOSE) -07

Umukobwa wa Miao agera kubisubizo byuzuye nyuma yubuvuzi bwa CAR-T nyuma yo kwimurwa nyuma yo kwimurwa.

Amei, umunyeshuri wicyiciro cya kabiri cya kaminuza ya Hunan wo mu bwoko bwa Miao, yari yasohoye impapuro ebyiri za SCI. Ku ya 2 Mata 2020, yinjiye mu bitaro by'intara kubera umuriro mwinshi. Isuzuma ry'amagufwa yamusuzumye afite lymphoblastique ikaze (T-BYOSE). Nyuma yamasomo menshi ya chimiotherapie mubitaro byo hanze, igufwa rye ryagumye kumererwa neza. Ku ya 2 Ugushyingo 2020, yatewe ingirabuzimafatizo ya allogeneic hematopoietic stem selile mu bitaro byacu (umuvandimwe-mushiki wawe, umukino wa HLA 7/10). Nyuma yo guhindurwa, ingirabuzimafatizo zakozwe neza, hamwe no gukurikirana amagufwa yo mu magufa yerekanaga ko yakize neza.

Ku ya 16 Kamena 2021 (amezi 7 nyuma yo kwimurwa), kwisuzumisha bisanzwe byagaragaje ko indwara ya leukemia yongeye kugaruka. Nyuma ya chimiotherapie yananiwe kurwanya indwara, maze arwara umusonga na virusi ya herpes, hamwe n'ibisebe bibabaza byo mu kanwa bituma kumira bigoye. Yinjiye mu cyiciro cya kabiri cy’ishami ry’amaraso kandi yiyandikisha mu igeragezwa rya CD7 CAR-T.

Itsinda ry’ubuvuzi rya Diregiteri Yang Junfang ryatanze imiti igabanya ubukana, kugabanya ububabare, no guterwa amaraso menshi na platine. Bitewe nuburemere bukabije bwibibyimba (80% biturika mumagufwa na 97% biturika mumaraso ya peripheri), ntibyashobokaga kwegeranya selile. Amaraso ya lymphocytes ya periferique yatanzwe n'umuterankunga (murumuna we) yakusanyirijwe hamwe yoherezwa muri sosiyete ikora ibijyanye na biotech kugirango umuco w'akagari ka CAR-T.

Ku ya 10 Kanama 2021, CD7 CAR-T ikomoka ku baterankunga yongeye gushyirwaho. Nyuma yo kongera gushyirwamo imbaraga, selile CAR-T yagutse igera kuri 54,64% mumaraso ya periferiya, ifite umuriro gusa kandi nta syndrome ya cytokine irekura (CRS) cyangwa indwara ya graft-na host-host (GVHD). Isuzuma ry'amagufwa kumunsi wa 16 nyuma yo kongera kwerekanwa ryerekanwe neza, hamwe na selile 54.13% CAR-T mumitsi. Ku munsi wa 36, ​​igufwa ryamagufa ryakomeje kwerekana ko rihoraho. Kugeza ubu, imitekerereze ye, ibitotsi, no kurya, ni byiza, kandi arimo gukira neza.