Indwara ya Lymphoblastique ikaze (T-BYOSE) -06

Umwana wimyaka 2 wumurwayi wabana hamwe na T-ALL ageraho gukira nyuma yubuvuzi bwa CAR-T nyuma yimirongo irenga icumi ya chimiotherapie ikomeye.

Xiaohong w'imyaka ibiri ukomoka muri Zhejiang bamusanganye indwara ya leukemia mu mpeshyi ishize. Nyuma yumwaka urenga wivuwe, cytometrie itemba yongeye kugaruka, bituma umuryango ushakisha ubudahangarwa bwa CAR-T mubitaro bya Lu Daopei.

Ku ya 9 Kanama 2020, Xiaohong yinjiye mu bitaro by’abana baho kubera "umuriro w’iminsi itatu." Amagufwa ya marike MICM yasuzumye indwara ya lymphoblastique ikaze (T-BYOSE). Nyuma yisomo rimwe rya chimiotherapie, morphologie yamagufa yerekanaga ko yakize neza, kandi cytometrie itemba yasanze nta selile mbi idakuze. Nyuma ya chimiotherapie yibyiciro birenga 11 byakomeje gukuraho burundu amagufwa.

Ku ya 3 Nzeri 2021, gukurikirana amagufwa yo mu magufa yerekanaga ko yakiriye neza muri morfologiya, ariko cytometrie yerekana ko 1.85% ingirabuzimafatizo zidakuze. Mu gushaka ubundi buvuzi, Xiaohong yinjiye mu bitaro bya Yanda Lu Daopei ku ya 24 Nzeri. Akimara kwinjira, morphologie yo mu magufa yari ikiri mu buryo bwuzuye, ariko immunophenotyping yerekanaga 0,10% lymphocytes T idakuze.

Urebye imyaka Xiaohong akiri muto ndetse no kuba iyi ndwara ikomeje kubaho nubwo hashyizweho inshuro zirenga icumi za chimiotherapie, itsinda ry’abaganga bo mu cyiciro cya kabiri cy’ishami ry’ubuvuzi bw’amaraso ryemeje ko Xiaohong ashobora kwiyandikisha mu isuzuma ry’amavuriro rya CD7 CAR-T.

Ku ya 30 Nzeri 2021, ingirabuzimafatizo z'amaraso zegeranijwe kugira ngo umuco wa CAR-T utangwe. Ku ya 10 Ukwakira, Xiaohong yakiriye chimiotherapie ya FC regimen. Ku ya 13 Ukwakira, igufwa ryo mu magufa ryerekanaga ibisasu bitageze kuri 5% muri morphologie, naho cytometrie yerekana 0.37% ingirabuzimafatizo T idakuze. Ku ya 15 Ukwakira, CD7 CAR-T selile zongeye gushyirwaho.

Ku ya 3 Mutarama (iminsi 20 nyuma ya reinfusion), igufwa ryamagufa ryerekanaga ko ryakuwe neza muri morphologie, nta selile zidakuze zamenyekanye na cytometrike. Kuva icyo gihe Xiaohong yarushijeho kuba mwiza, kandi yimuriwe mu ishami rishinzwe guhindurwa kugira ngo yitegure kwimura ingirabuzimafatizo ya allogeneic hematopoietic stem selile.

Xiaohong yari atarageza ku mwaka umwe igihe yarwaraga yihanganira umwaka urenga imiti. Ikiraro cyiza cyo kwimurwa nyuma yubuvuzi bwa CD7 CAR-T bwatanze intwaro ikomeye yo gutsinda burundu indwara.