Nkhondo ya Wu: Kudwala myeloma yambiri

Patient Wu, wamwamuna wazaka 71, adapezeka ndi myeloma yambiri.

Adakalandira chithandizo ku Bioocus International Medical Center mu 2022 ndipo wakhutira kwambiri ndi chisamaliro chake. Matenda oyambilira adavumbulutsa zomwe zapezedwa pa MRI ndi T5T, kuphatikiza T10, T11, ndi L1 cone fractures ndi edema ya m'mafupa. Kuphatikiza apo, zizindikiro zazing'ono zachilendo zidawonedwa mu L2 vertebral body. A vertebral puncture biopsy inatsimikizira plasma cell myeloma. Kufufuza kwina kunawonetsa plasma ya prokaryotic yomwe ili ndi 46% ya mafupa a mafupa, omwe ali ndi maselo osadziwika bwino omwe amapanga 14% mu flow cytometry. Bone junction biopsy imasonyeza 70% problastoma. Kusanthula kwa NSOMBA kunavumbula kutayika kwa majini mu lq21 (CKSIB) ndi 1m32 (CDKN2C), pomwe kuyesa kwa FTSH kunali kwabwino pakuchotsa jini ya p53, ndipo ICH inali yoyipa pakuyesa kwa FISH. Kuzindikira komaliza kunali multiple osteoblastic follipoma (L light chain type), yokhala ndi DS mu siteji B, ISS staging III, ndi RISS staging mu Stage II. Patient Wu adathokoza chifukwa cha chithandizo chokwanira komanso chamunthu payekha chomwe achipatala amapereka.

Mbiri yakale yamankhwala:

Mawonetseredwe azachipatala a myeloma angapo ndi osiyanasiyana, makamaka kuphatikizapo kuchepa kwa magazi m'thupi, kupweteka kwa mafupa, kulephera kwaimpso, matenda, magazi, zizindikiro za mitsempha, hypercalcemia, ndi chimbudzi cha amyloid. Chipatalacho chinachita mankhwala amphamvu oletsa matenda ndi kuwongolera magazi m’thupi ndi mapulateleti ochepa. Pafupifupi miyezi iwiri pambuyo pa kulowetsedwa kwa selo la BCMA CAR-T, zizindikiro za wodwalayo pang'onopang'ono zinabwerera mwakale, ndipo matenda ake anali kulamulira. Bioocus International Medical Center yakhala ikuyang'anira wodwalayo mosalekeza kuti atsimikizire kukhazikika kwa zotsatira za chithandizo.