Systemic Lupus Erythematosus (SLE)-04

Ali ndi zaka 7, Yaoyao (dzina lachinyengo) anayamba kuona kutuluka kwa zidzolo zofiira kumaso kwake, zomwe zinafalikira pang'onopang'ono thupi lake lonse. Kuwonjezera pa zizindikiro zimenezi, iye ankakhala ndi zilonda zam'kamwa mobwerezabwereza komanso m'malo opweteka m'malo olumikizirana mafupa, zomwe zinachititsa kuti banja lake lipite kuchipatala. Atapimidwa bwinobwino kuchipatala, Yaoyao anamupeza ndi matenda a systemic lupus erythematosus (SLE), omwe amadziwika kuti ndi ovuta komanso osadziwika bwino.

M’kupita kwa zaka zitatu, Yaoyao analandira chithandizo chamankhwala champhamvu kwambiri ndipo amamutsatira pafupipafupi kuchipatala. Ngakhale kuti mlingo wa mankhwalawo ukuchulukirachulukira, matenda ake sanasinthe kwenikweni. Momwemonso, proteinuria yake, chizindikiro cha kukhudzidwa kwa impso mu SLE, idapitilira kukulirakulira, ndikuyambitsa kupsinjika ndi nkhawa pakati pa achibale ake.

Kupyolera mwa kutumiza kwa bwenzi lake lodalirika, Yaoyao adadziwitsidwa ku chipatala cha Lu Daopei, komwe adachita nawo mayeso owopsa a CAR-T. Kutsatira njira yowunikira kwambiri, adavomerezedwa mumlanduwo pa Epulo 8. Kenako, pa Epulo 22, adatenga ma cell, ndipo pa Meyi 12, adalandira kulowetsedwa kwa ma cell omwe amathandizidwa ndi CAR-T. Kutulutsidwa kwake bwino pa Meyi 27 kudakhala nthawi yofunikira kwambiri paulendo wake wamankhwala.

M'mwezi woyamba wotsatira, akatswiri azachipatala adawona kupita patsogolo kwakukulu, makamaka kuchepa kwa proteinuria. Pamaulendo otsatira, zotupa pakhungu lake zinali zitangotsala pang’ono kuzimiririka, ndipo patsaya lake lakumanja linali ndi totupa pang’ono chabe. Mwamwayi, proteinuria yake idathetsedwa kwathunthu, ndipo zotsatira zake za SLE Disease Activity Index (SLEDAI-2K) zidawonetsa matenda ochepa, osakwana 2.

Pothandizidwa ndi mphamvu ya CAR-T cell therapy, Yaoyao pang'onopang'ono anasiya kumwa mankhwala ake moyang'aniridwa ndi achipatala. Chochititsa chidwi n'chakuti wakhala wopanda mankhwala kwa miyezi inayi, kutsimikizira kuti kukhululukidwa kosalekeza kumatheka chifukwa cha njira yatsopano yochizira.

Ulendo wa Yaoyao ukugogomezera za kuthekera kosinthika kwa chithandizo cha CAR-T pakuwongolera zovuta za autoimmune monga SLE, kupereka chiyembekezo ndi zotulukapo zowoneka bwino komwe chithandizo chachikhalidwe chingalephereke. Zomwe adakumana nazo zikuwonetsa chiyembekezo kwa odwala ndi mabanja omwe akukumana ndi zovuta zofananira, zomwe zikuwonetsa tsogolo labwino lamankhwala amunthu payekha pakuwongolera matenda a autoimmune.