Systemic Lupus Erythematosus (SLE)-01

Xiaohuan wazaka 24 wakhala akuphunzira zamankhwala ku yunivesite kwa zaka zitatu ndipo wakhala akudwala systemic lupus erythematosus (SLE) kwa zaka pafupifupi 10. "Ndinapezeka ndi zaka 10, ndipo adotolo adati zinali zovuta kwambiri kuchiza, kuti ndimatha kuwongolera ndi mankhwala," adatero Xiaohuan akumwetulira kowawa. M’zaka khumi zapitazi, anafunika kupita kukapimidwa mwezi ndi mwezi ndi kupatsidwa mankhwala, ndipo analandira chithandizo chamankhwala a mahomoni, machiritso oletsa chitetezo chathupi, ndi machiritso a tizilombo toyambitsa matenda, koma palibe chimene chinathandiza. Anapirira kuthothoka tsitsi kwambiri, zidzolo zambiri, kutentha thupi kosalekeza, ndi ululu wofala.

Pambuyo pakuyezetsa koyambirira koyambirira, Xiaohuan adakwaniritsa zofunikira zonse zachipatala cha CAR-T chithandizo cha SLE. Gulu lina la akatswiri linapanga mosamala dongosolo la chithandizo chotengera momwe alili komanso kukonzekera bwino ntchito yotolera ma cell. Pa Marichi 28, kusonkhanitsa ma cell a mononuclear kudayamba. Pa Epulo 22, adayamba chemotherapy ya lymphodepleting. Pa Epulo 28, ma cell adalowetsedwanso. Ma cell mamiliyoni makumi awiri a T osinthidwa ndi CAR adalowetsedwa pang'onopang'ono mumtsempha wa Xiaohuan, akulunjika mwachindunji ma cell a lupus B, ndikuyambitsa "kuukira kolondola, kuswa imodzi ndi imodzi".

Pa Juni 4, tsiku la 38 atalowetsedwa, Xiaohuan adabwerera kuchipatala kuti akatsatire. Zotsatira za mayesowo zikuwonetsa kuti zizindikiro zonse zofunikira zidatsikira kumayendedwe oyenera. "Sindikufunikanso mankhwala a mahomoni; zikuwoneka ngati moyo ukungoyamba kumene," Xiaohuan adatero mosangalala.