Shawn [Dzina Lomaliza Sanaperekedwe]----Acute B-lymphocytic Leukemia (B-ALL)

Kuyesa kwabwino kwachipatala kwa CAR-T kumapulumutsa odwala ku Hong Kong B-ALL.

Shawn, ndi bambo wa zaka 29 wa ku Hong Kong. Mu Marichi 2017, ali ndi zizindikiro za kutentha thupi, kutopa komanso kufooka. Anamupeza ndi acute B-lymphocytic leukemia pachipatala cha Prince of Wales ndipo adalandira chithandizo chamankhwala. Mu April adalandira chikhululukiro chonse ndi chemotherapy ndi radiotherapy. Ndipo palibe zolakwika zomwe zidapezeka mu lipoti la CSF correlation.

Komabe, mpaka 19 Epulo 2018, morphology ya mafupa ake idawonetsa 10% ya chinzonono cha pulaimale ndi yachinyamata. Madokotala aku Hong Kong akuganiza kuti chemotherapy ndiyovuta kumupangitsa kuti akhululukidwe kwathunthu, ndi CAR-T yokhayo yomwe ili ndi mwayi waukulu kuti ipange. Pambuyo pa malingaliro a madotolo ndikuyerekeza momwe zinthu zikuyendera komanso kuyesetsa kwake, Shawn adabwera kuchipatala cha Lu Daopei ku China kuti achite nawo mayeso azachipatala a CAR-T pa 23 Epulo 2018.

Mayeso ovomerezeka a mafupa a mafupa adawonetsa kuti sanakhululukidwe ndipo CD19, CD20 ndi zabwino. Pambuyo pokambirana ndi magulu osiyanasiyana, akatswiri athu a hematologists amati achite nawo mayeso a CD19+CD20 CAR-T asanamuike m'mafupa. M'milandu yathu 300 ya CAR-T, chiwopsezo chonse cha kukhululukidwa ndi pafupifupi 90%.

Pa 25 Epulo, ma T-cell a Shawn adasonkhanitsidwa ndikutumizidwa ku labotale ya GMP CAR-T kuti apange genetic engineering. Atasinthidwa ma genetic, ma T-cell adasinthidwa kukhala "chimeric antigen receptor (CAR) T-maselo". Ma CAR ndi mapuloteni omwe amathandiza kuti ma T-cell azindikire antigen m'maselo a chotupa omwe akulunjika. Maselo a CAR T akakula mpaka kufika pamlingo wokwanira kuti alandire chithandizo, ma cell a CAR T amalowetsedwa m'maselo kuti athetse chotupacho.

Shawn adalandira 1 kosi ya chemotherapy pa 6 Meyi, yomwe ili masiku 5 isanachitike kulowetsedwa kwa cell ya CAR-T. Pa Meyi. Pa Meyi 11, kulowetsedwa kwa ma cell a CD19 CAR-T kunaperekedwa ngati ma cell immunotherapy. Pambuyo pa masabata a 4 a chithandizo chothandizira ndi kasamalidwe ka zotsatira zake, palibe zolakwika zomwe zinapezeka mu lipoti la CSF correlation, flow cytometry, bone marrow cell morphology, DNA test ndi lipoti la CAR-T linasonyeza kuti adakhululukidwa kwathunthu.

Kukhala wokhululukidwa kotheratu ndiyo njira yabwino koposa yakuti abwerere ku Hong Kong kaamba ka sitepe yotsatira—kuika magazi ndi fupa.