Ocular melanoma (poyamba), yotsatiridwa ndi zotupa za chiwindi za metastatic-02

Mu 2021, Mayi Y mwadzidzidzi adawona kusawona bwino kwa diso lawo lakumanja. Atamuyeza bwinobwino anapeza kuti anali ndi khansa ya m’maso. Mwamwayi, idadziwika koyambirira ndikuyikidwa ngati siteji 1A, ndi mwayi wa 2% wa metastasis. Atalandira chithandizo cha radiotherapy, sanakhalepo ndi khansa kwa kanthaŵi, ngakhale kuti mtengo wake unali wakhungu losatha m’maso okhudzidwawo.

Komabe, mwatsoka, chotupacho chinabwereranso chaka chotsatira ndipo chinayamba kukula mofulumira. Kujambula kunasonyeza kuti chiwindi chake chinali kale ndi zotupa khumi za kukula kosiyanasiyana. Chifukwa chake, akatswiri adalimbikitsa kuti achite nawo mayeso achipatala a TIL (chotupa-infiltrating lymphocyte).

Bambo a Mayi Y ndi amuna awo anasonkhanitsa zolemba zake zachipatala ndipo analankhulana ndi madokotala m'dziko lonselo kuti apeze mayesero oyenerera achipatala, potsirizira pake anapeza pulogalamu yathu. Njira imeneyi imagwiritsa ntchito maselo oteteza thupi ku matenda a khansa.

Madokotala anachotsa mbali ina ya chotupacho m’chiwindi cha Mayi Y, n’kuchikulitsa n’kufika pa 10 mpaka 150 biliyoni, n’kupanga gulu lankhondo la clone cell. Gulu lankhondo lalikululi linalowetsedwanso m'thupi lake kuti liwononge maselo a khansa molondola, mwamphamvu, komanso mosalekeza.

Kulima kwa maselo a TIL kunatenga pafupifupi milungu itatu ndipo kumangofunika gawo limodzi lokha la chithandizo. Mu Seputembala 2023, Mayi Y adalandira chithandizo chamankhwala kwa sabata imodzi, kulowetsedwa kwa TIL, ndi IL-2. Kuchiza koopsa kumeneku kunayambitsa mavuto aakulu, kuphatikizapo kupweteka kwa mafupa, kupuma, zizindikiro za m'mimba, zotupa, ndi mutu waukulu.

Komabe, zotsatira zoyipazi zitatha, chozizwitsa chinachitika. Chithandizo cha TIL chidawoneka chothandiza kwambiri. M’chaka chimodzi, pafupifupi zotupa zonse za Mayi Y zinali zitazimiririka kapena kucheperachepera, n’kutsala imodzi yokha. Mu 2024, madotolo adachotsa pafupifupi theka lachiwindi chake, kuphatikiza chotupa chomaliza. Atadzuka, anauzidwa kuti m’thupi mwake mulibe zizindikiro za matenda.