Chipatala cha Lu Daopei Chipatala Chochepa cha CD19 CAR-T Chimawonetsa Zotsatira Zabwino Kwa Odwala a B-ALL

Pakafukufuku wochititsa chidwi yemwe adachitika ku chipatala cha Lu Daopei, ofufuza anena za kupita patsogolo kwakukulu pamankhwala ochizira kapena kubwereranso kwa B acute lymphoblastic leukemia (B-ALL) pogwiritsa ntchito mankhwala a CD19 otsogozedwa ndi CAR-T cell ochepa. Kafukufukuyu, yemwe adakhudza odwala 51, adawulula kuti njira yatsopanoyi sinangopeza ziwongola dzanja zapamwamba (CR) komanso idasunga mbiri yabwino yachitetezo.

Gulu lofufuza, lotsogoleredwa ndi Dr. C. Tong wochokera ku Dipatimenti ya Hematology ndi Dr. AH Chang wochokera ku Clinical Translational Research Center ku Tongji University School of Medicine, adafufuza zotsatira za kupereka mlingo wochepa wa maselo a CAR-T-pafupifupi 1. × 10 ^ 5 / kg-poyerekeza ndi mlingo wapamwamba wamba. Njira imeneyi inali yolinganiza mphamvu zochiritsira ndi kuchepetsa zotsatira zoyipa, makamaka cytokine release syndrome (CRS).

Zotsatira za phunziroli zinali zokopa. Pakati pa 42 odwala B-ALL odwala, 36 adapeza CR kapena CR ndi chiwerengero chosakwanira (CRi), pamene odwala asanu ndi anayi onse omwe ali ndi matenda ochepa otsalira (MRD) adafika ku MRD kunyalanyaza. Kuphatikiza apo, odwala ambiri adangokumana ndi CRS yofatsa mpaka yocheperako, pomwe milandu yayikulu imayendetsedwa bwino pogwiritsa ntchito njira zoyambira.

Dr. Tong anatsindika kufunika kwa phunziroli, ponena kuti, "Zotsatirazi zikusonyeza kuti CD19 CAR-T cell therapy yochepa kwambiri, yotsatiridwa ndi allogeneic hematopoietic stem cell transplantation (allo-HCT), imapereka njira yochiritsira yothandiza kwambiri kwa odwala omwe ali ndi vuto la magazi. Njira zina zocheperako Thandizoli silimangopereka chiwongola dzanja chachikulu komanso chimachepetsa chiopsezo cha zovuta zoyipa.

Kupambana kwa kafukufukuyu kumatsimikizira kuthekera kwa njira zochiritsira zama cell a CAR-T pochiza matenda ovuta a hematological. Chipatala cha Lu Daopei, chodziwika bwino chifukwa cha ntchito yake yochita upainiya mu ma cell immunotherapy, chikupitilizabe kupereka chithandizo chamankhwala kwa odwala omwe ali ndi vuto la hematologic.

Pamene kafukufukuyu akupita patsogolo, gulu lofufuza likuyembekeza kukonzanso mlingo ndi ndondomeko kuti ziwongolere zotsatira za odwala. Zotsatira za kafukufukuyu zasindikizidwa m'magaziniLeukemiandikupereka chiyembekezo kwa odwala B-ALL padziko lonse lapansi.