Kugwiritsa Ntchito Nthawi Yaitali kwa CD19 CAR T-Cell Therapy pochiza Kuyambiranso / Refractory Acute Lymphoblastic Leukemia
Pakupita patsogolo kwakukulu pankhani ya hematology, kafukufuku waposachedwa wawonetsa mphamvu yanthawi yayitali ya CD19 chimeric antigen receptor (CAR) T-cell therapy kwa odwala omwe akudwala relapsed/refractory acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem. cell transplantation (allo-HSCT). Phunziroli, lomwe limatsatira odwala kwa nthawi yayitali, limapereka kusanthula kwatsatanetsatane kwa zotsatira zake, kupereka zidziwitso zamtengo wapatali za kukhalitsa ndi chitetezo cha mankhwala atsopanowa.
Kafukufukuyu adatsata mosamala odwala omwe adalandira chithandizo cha CD19 CAR T-cell atakumananso ndi ONSE kutsatira allo-HSCT. Zotsatirazo zikulonjeza, kusonyeza kuti chiwerengero chachikulu cha odwala adapeza chikhululukiro chathunthu, ndi mayankho okhazikika omwe adawonedwa pazaka zambiri. Kafukufukuyu akugogomezera mphamvu zochiritsira za CAR T-cell therapy komanso zikuwonetseratu zofunikira kwambiri pochiza matenda a hematological malignancies, makamaka kwa omwe ali ndi njira zochepa zothandizira.
Kuphatikiza apo, kafukufukuyu amayang'ana mbiri yachitetezo chamankhwala, ndikuwonetsa zotsatira zoyipa zomwe zimatha kuyendetsedwa, zomwe zinali zogwirizana ndi zomwe zidapezeka kale. Izi zimalimbitsa chidaliro chomwe chikukulirakulira mu chithandizo cha CAR T-cell ngati chithandizo chotheka komanso chothandiza pakuyambiranso/kukaniza ONSE, makamaka pakasinthidwe kakumuika.
Pamene gawo la immunotherapy likupitilirabe, kafukufukuyu amakhala ngati chiyembekezo kwa odwala komanso othandizira azaumoyo, ndikulonjeza tsogolo lomwe odwala ambiri atha kukhululukidwa kwa nthawi yayitali. Zomwe zapezedwa sizimangowonjezera kuchuluka kwa umboni wochirikiza chithandizo cha CAR T-cell komanso kutsegulira njira yopititsira patsogolo kufufuza ndikukulitsa kugwiritsidwa ntchito kwake m'machipatala.
Pochita izi, azachipatala akuyandikira kusintha momwe chithandizo chamankhwala amachitira matenda a hematological, kupatsa chiyembekezo kwa odwala omwe akulimbana ndi zovutazi.