Njira Zatsopano Zochizira Maselo a CAR-T Amasintha Machiritso a B Ma cell Malignancies

Mu ndemanga yaposachedwa yomwe idasindikizidwa mu Journal of the National Cancer Center, akatswiri a Lu Daopei Hospital, motsogozedwa ndi Dr. Peihua Lu, pamodzi ndi ogwira nawo ntchito ku The University of Texas MD Anderson Cancer Center, akuwunikira zomwe zapita patsogolo ku CAR-T. ma cell mankhwala ochizira B-cell malignancies. Ndemanga yonseyi ikukamba za njira zingapo zatsopano, kuphatikizapo kusinthika kwa mapangidwe a maselo a CAR-T ndi kuphatikiza kwa njira zochiritsira za cell, kuti apititse patsogolo mphamvu ndi chitetezo cha mankhwala a matenda monga non-Hodgkin's lymphoma (NHL) ndi acute lymphoblastic leukemia (ALL). ).

Matenda a B-cell amabweretsa zovuta zazikulu chifukwa cha chizolowezi chawo chobwerera m'mbuyo ndikuyamba kukana mankhwala ochiritsira. Kuyambitsidwa kwa ma cell a chimeric antigen receptor (CAR) T kwasintha mawonekedwe achirengedwe, kupereka chiyembekezo chatsopano kwa odwala omwe akukumana ndi makhansa oopsawa. Kafukufukuyu akuwonetsa momwe ma cell a CAR T angapangidwe ndi mibadwo ingapo yamapangidwe, kuphatikiza zida zapamwamba monga zolandilira bispecific ndi madera okwera mtengo, kuti athe kulunjika bwino ma cell chotupa ndikuchepetsa mwayi wobwereranso.

Chipatala cha Lu Daopei chakhala patsogolo pakufufuza kwa ma cell a CAR-T ndikugwiritsa ntchito kuchipatala, kuwonetsa kupambana kwakukulu pakupangitsa kuti akhululukidwe kwa nthawi yayitali. Kugwira ntchito kwa chipatalachi pa ntchito yochita upainiya kumasonyeza kudzipereka kwake kupititsa patsogolo chithandizo cha khansa ndi kupereka chithandizo chamakono. Ndemangayi ikuyang'ananso kuthekera kophatikiza mankhwala a CAR-T ndi mankhwala ena, monga immunotherapy ndi mankhwala omwe akuwongolera, kuti athetse njira zotsutsa ndikuwongolera zotsatira za odwala.

Bukuli ndi umboni wa kuyesetsa kwa ofufuza apadziko lonse lapansi ndi asing'anga pokankhira malire a chithandizo cha khansa. Zomwe zapezazi zikupereka chithunzithunzi chamtsogolo cha oncology yolondola, pomwe chithandizo chamunthu payekha komanso mwatsopano chingasinthe miyoyo ya odwala omwe akulimbana ndi zilonda za B cell. Zopereka za Chipatala cha Lu Daopei pankhaniyi ndizowunikira chiyembekezo, zomwe zikuyendetsa chitukuko chamankhwala otetezeka komanso ogwira mtima kwambiri a khansa.