Kupititsa patsogolo Mphamvu ya Antitumor ya 4-1BB-Maselo a CD19 CAR-T Pochiza B-ALL

Pakafukufuku wofunikira wachipatala wopangidwa ndi Lu Daopei Hospital ndi Lu Daopei Institute of Hematology, ofufuza apeza kuti ma cell a CD19 CAR-T okhala ndi 4-1BB amapereka njira ina yabwino yopangira ma CD28-based CAR-T cell pochiza omwe abwereranso kapena osasintha. B cell acute lymphoblastic leukemia (r/r B-ALL). Kafukufukuyu, wokhudzana ndi kufufuza mozama kwachipatala komanso kufufuza kwachipatala, adawonetsa kuti maselo a 4-1BB CAR-T samangopereka mphamvu yapamwamba ya antitumor komanso amasonyeza kulimbikira kwa nthawi yaitali kwa odwala poyerekeza ndi anzawo a CD28.

Gulu lofufuza la Chipatala cha Lu Daopei lidayerekeza mozama momwe ma cell a CAR-T awiriwa amagwirira ntchito. Iwo adapeza kuti, pansi pa kupanga komweko, maselo a 4-1BB CAR-T anali ndi mphamvu yotsutsa-tumor pa mlingo wochepa ndipo inachititsa kuti pakhale zovuta zochepa kwambiri kuposa ma CD28 CAR-T. Zotsatira za kafukufukuyu zikuwonetsa kuti chithandizo cha 4-1BB chochokera ku CAR-T chingapereke njira yothandiza komanso yotetezeka kwa odwala omwe ali ndi r/r B-ALL.

Zotsatirazi zikutsimikizira kudzipereka kwa Chipatala cha Lu Daopei kupititsa patsogolo hematology ndi immunotherapy, kupereka chiyembekezo kwa odwala omwe sanayankhe chithandizo chanthawi zonse. Kafukufukuyu, yemwe anatsatira mfundo zokhwima za makhalidwe abwino ndipo analandira chivomerezo kuchokera ku Komiti Yoona za Makhalidwe Abwino Chipatala cha Lu Daopei, akutsindika udindo wa chipatalacho potsogolera kafukufuku wamakono a CAR-T cell therapy.

Ndikuchita bwino uku, Lu Daopei Institute of Hematology ikupitilizabe kuchita upainiya watsopano mu kafukufuku wamankhwala, kupereka njira zotsogola zachipatala ndikuwongolera zotulukapo za odwala. Kupita patsogolo kumeneku ndi umboni wakudzipereka komanso ukadaulo wa magulu achipatala ndi kafukufuku achipatala cha Lu Daopei.