Zotsatira Zoyambitsa Matenda a CD7-Targeted CAR-T Therapy ya T-ALL ndi T-LBL

Mayesero aposachedwa azachipatala awonetsa kupita patsogolo kwakukulu pamankhwala a relapsed kapena refractory T-cell acute lymphoblastic leukemia (T-ALL) ndi T-cell lymphoblastic lymphoma (T-LBL) pogwiritsa ntchito CD7-targeted chimeric antigen receptor (CAR) T cell therapy. . Kafukufukuyu, wochitidwa ndi gulu lochokera ku chipatala cha Hebei Yanda Lu Daopei ndi Lu Daopei Institute of Hematology, adakhudza odwala 60 omwe adalandira mlingo umodzi wa maselo odana ndi CD7 CAR (NS7CAR) T osankhidwa mwachibadwa.

Zotsatira za mayesero ndi zolimbikitsa kwambiri. Pofika tsiku la 28, 94.4% ya odwala adakwanitsa kukhululukidwa kwathunthu (CR) m'mafupa. Kuonjezera apo, pakati pa odwala 32 omwe ali ndi matenda a extramedullary, 78.1% anasonyeza kuyankha kwabwino, ndi 56.3% kukwaniritsa chikhululukiro chonse ndi 21.9% kupeza chikhululukiro pang'ono. Kupulumuka kwazaka ziwiri zonse ndi kupulumuka kwaulere kunali 63.5% ndi 53.7%, motsatana.

Thandizo lamakonoli ndilofunika kwambiri chifukwa chachitetezo chake chokhazikika, chokhala ndi cytokine release syndrome yomwe imapezeka mu 91.7% ya odwala (makamaka giredi 1/2), ndi neurotoxicity yomwe imapezeka mu 5% ya milandu. Kuphatikiza apo, kafukufukuyu adapeza kuti odwala omwe adapitilira kuphatikizika pambuyo pokwaniritsa CR anali ndi chiwopsezo chambiri chopitilira kupulumuka poyerekeza ndi omwe sanatero.

Kampani yathu ikuyang'ananso kuthekera kwa CD7 CAR-T cell therapy ndi katundu wathu, cholinga chake ndikuthandizira kupititsa patsogolo chithandizo chamankhwala a T-cell.

Zomwe zapezazi zikugogomezera kuthekera kwa chithandizo cha CD7 chomwe chimayang'aniridwa ndi CAR-T cell kuti apereke chiyembekezo chatsopano kwa odwala omwe ali ndi T-ALL ndi T-LBL omwe abwerera m'mbuyo kapena obwerera m'mbuyo, zomwe zikuwonetsa gawo lalikulu pankhondo yolimbana ndi matenda ovutawa.