Kafukufuku Wopambana Akuwonetsa Chitetezo ndi Kuchita Bwino kwa CAR-T Therapy pochiza Matenda a B-Cell

Kafukufuku waposachedwapa wotsogoleredwa ndi Dr. Zhi-tao Ying wochokera ku Peking University Cancer Hospital wasonyeza zotsatira zodalirika pochiza matenda obwerezabwereza komanso otsutsa a B-cell hematologic pogwiritsa ntchito buku lachimeric antigen receptor T (CAR-T) cell therapy, IM19. Lofalitsidwa muChinese Journal of New Drugs, kafukufukuyu akuwonetsa kuthekera kwakukulu kwachirengedwe ka IM19 kwa odwala omwe atopa njira zochiritsira zochiritsira.

Kafukufukuyu adakhudza odwala 12, omwe amagawidwa mofanana pakati pa omwe akudwala B-cell non-Hodgkin lymphoma (NHL) ndi acute B-cell lymphoblastic leukemia (B-ALL). Odwalawo anachiritsidwa ndi mitundu yosiyanasiyana ya maselo a IM19 CAR-T, omwe adalowetsedwa pambuyo pa ndondomeko yowonongeka yomwe imaphatikizapo fludarabine ndi cyclophosphamide. Mfundo zazikuluzikulu za phunziroli zinaphatikizapo kuwunika momwe akuyankhira, kulimbikira kwa maselo a CAR-T, kumasulidwa kwa cytokine, ndi kuyang'anira zochitika zovuta.

(Chithunzi chikuwonetsa kuchira kwa odwala a NHL ndi B-ALL)

Chodabwitsa ndichakuti, 11 mwa odwala 12 adakhululukidwa kwathunthu, ndikuchulukira kwa IM19 m'magazi awo. Chithandizocho chinapangitsa kuti ma cytokines achuluke monga interleukin-6 ndi interleukin-10, zomwe zikuwonetsa kuyankha kwamphamvu kwa chitetezo chamthupi. Chofunika kwambiri, palibe odwala omwe adakumana ndi vuto lalikulu la kutulutsidwa kwa cytokine kapena CAR-T cell-related encephalopathy, kutsimikizira mbiri yachitetezo cha mankhwalawa.

Kafukufukuyu adachitidwa ndi gulu logwirizana kuchokera ku Peking University Cancer Hospital, Hebei Yanda Lu Daopei Hospital, ndi Beijing Immunochina Pharmaceuticals. Dr. Ying, yemwe ndi wolemba wamkulu, amagwira ntchito yofufuza ndi kuchiza ma lymphomas owopsa, pomwe Dr. Jun Zhu, wolemba wofananayo, ndi katswiri wodziwika bwino pantchito yomweyi. Kafukufukuyu adathandizidwa ndi ndalama zambiri zotsogola, kuphatikiza National Natural Science Foundation yaku China ndi Beijing Natural Science Foundation.

Kafukufuku wodabwitsayu akupereka umboni wokwanira kuti chithandizo cha IM19 CAR-T sichitha kokha komanso ndi chotetezeka kwa odwala omwe ali ndi vuto la B-cell malignancy. Imatsegula njira ya kafukufuku wamtsogolo ndi zomwe zingagwiritsidwe ntchito pachipatala, kupereka chiyembekezo chatsopano kwa odwala omwe ali ndi njira zochepa zochiritsira.