Bioocus Imatsogoza Patsogolo Pakuchiza Ana Acute Lymphoblastic Leukemia

Chinthu chofunika kwambiri pa chithandizo cha CAR-T, chodziwika ndi kusindikizidwa kwaposachedwa kwa kafukufuku wochititsa chidwi wotsogoleredwa ndi Dr. Chunrong Tong ku Lu Daopei Hospital. Kafukufukuyu, wotchedwa "Experience and Challenges of Second-Generation CD19 CAR-T Cell Therapy in Pediatric Acute Lymphoblastic Leukemia," akupereka kusanthula kwathunthu kwa mphamvu ndi chitetezo cha CD19 CAR-T cell therapy ya m'badwo wachiwiri pochiza ana acute lymphoblastic leukemia. (Zonse).

Kafukufukuyu akugogomezera kuthekera kwatsopano kwa mankhwala a Bioocus's CAR-T pothana ndi vuto limodzi lovuta kwambiri la hematological mwa ana. Kafukufukuyu akulongosola bwino za zotsatira zachipatala zomwe zimawonedwa mwa odwala omwe adalandira mankhwalawa, kuwulula ziwongola dzanja zodalirika. Komabe, imazindikiritsanso zovuta zazikulu, makamaka kasamalidwe ka matenda oopsa a cytokine release (CRS) ndi neurotoxicity, zomwe zimakhalabe madera ofunikira kwambiri pakuwongolera chitetezo cha odwala.

Bioocus's CAR-T therapy, yomwe ili mu kafukufukuyu, imagwiritsa ntchito mapangidwe a m'badwo wachiwiri omwe amapangitsa kuti T-cell igwire ntchito motsutsana ndi ma cell a khansa omwe amawonetsa CD19 antigen. Njira iyi ndiyofunikira kwambiri pothana ndi zovuta zomwe zimakumana ndi ana omwe abwereranso kapena okana matenda ONSE. Zotsatira zomwe zaperekedwa m'bukuli sizimangowonetsa mphamvu zochiritsira za Bioocus's CAR-T mankhwala komanso zimatsindika kufunikira kwa luso lopitiliza komanso kafukufuku wachipatala kuti akonzenso njira zochiritsirazi.

Kafukufuku wa Dr. Tong amathandizira kuzindikira kofunikira pakugwiritsa ntchito njira zochiritsira za CAR-T ndipo zimagwirizana ndi cholinga cha Bioocus chopititsa patsogolo chithandizo cha khansa kudzera munjira zotsogola zasayansi. Monga mtsogoleri wapadziko lonse pa chitukuko cha CAR-T, Bioocus adakali wodzipereka kukankhira malire a zomwe zingatheke pochiza khansa, ndi cholinga chachikulu chothandizira zotsatira za odwala ndi moyo wabwino.

Pamene Bioocus akupitiriza kugwirizana ndi zipatala zotsogola monga Chipatala cha Lu Daopei, timakhala odzipereka kuti tithane ndi zovuta zomwe zapezeka mu kafukufukuyu ndi kuyenga mankhwala athu a CAR-T kuti apititse patsogolo chitetezo ndi mphamvu zawo. Kudzipereka kwathu pakuchita bwino komanso zatsopano kumatsimikizira kuti tili okonzeka kutsogolera tsogolo la chithandizo cha khansa.