Kodi Chithandizo cha Ma Cellular Ndi Tsogolo la Matenda a Autoimmune?

Chithandizo chosintha cha khansa chingathenso kuchiza ndikukhazikitsanso chitetezo chamthupi kuti chichepetse nthawi yayitali kapenanso kuchiza matenda ena a autoimmune.

Chimeric antigen receptor (CAR) T-cell therapy yapereka njira yatsopano yochizira khansa ya hematologic kuyambira 2017, koma pali zizindikiro zoyamba kuti ma immunotherapies am'manjawa atha kubwezeredwa chifukwa cha matenda a B-cell mediated autoimmune.

Mu Seputembala chaka chatha, ofufuza ku Germany adanenanso kuti odwala asanu omwe ali ndi refractory systemic lupus erythematosus (SLE) adalandira chithandizo cha CAR T-cell onse adakhululukidwa popanda mankhwala. Panthawi yofalitsidwa, palibe odwala omwe adayambiranso kwa miyezi 17 atalandira chithandizo. Olembawo adafotokoza za seroconversion ya ma antibodies a antinuclear mwa odwala awiri omwe amatsatira motalika kwambiri, "kuwonetsa kuti kuchotsedwa kwa ma cell a autoimmune B-cell kungayambitse kuwongolera kufalikira kwa autoimmunity," ofufuzawo alemba.

Mu kafukufuku wina wofalitsidwa mu June, ofufuza adagwiritsa ntchito CD-19 yomwe imayang'aniridwa ndi maselo a CAR-T kuti athandize bambo wazaka 41 yemwe ali ndi matenda a refractory antisynthetase omwe ali ndi matenda a myositis ndi interstitial mapapu matenda. Miyezi isanu ndi umodzi mutalandira chithandizo, panalibe zizindikiro za myositis pa MRI ndi chifuwa cha CT scan chinasonyeza kutayika kwathunthu kwa alveolitis.

Kuyambira pamenepo, makampani awiri a biotechnology - Cabaletta Bio ku Philadelphia ndi Kyverna Therapeutics ku Emeryville, California - apatsidwa kale mayina achangu kuchokera ku US Food and Drug Administration ya CAR T-cell therapy ya SLE ndi lupus nephritis. Bristol-Myers Squibb akuchititsanso kuyesa kwa gawo 1 kwa odwala omwe ali ndi SLE yoopsa, yosakanizika. Makampani angapo a biotechnology ndi zipatala ku China akuyesanso zachipatala za SLE. Koma izi ndi nsonga chabe ya mankhwala ochizira ma cell a matenda a autoimmune, atero a Max Konig, MD, PhD, pulofesa wothandizira wamankhwala pagawo la rheumatology ku Johns Hopkins University School of Medicine ku Baltimore.

"Ndi nthawi yosangalatsa kwambiri. Sizinachitikepo m'mbiri ya autoimmunity," adatero.

"Kuyambiranso" kwa Immune System

Njira zochiritsira zolimbana ndi ma cell za B zakhala zikuchitika kuyambira koyambirira kwa zaka za m'ma 2000 ndi mankhwala monga rituximab, mankhwala a monoclonal antibody omwe amalimbana ndi CD20, antigen yowonetsedwa pamwamba pa ma B cell. Ma cell a CAR T omwe alipo pano amayang'ana ma antigen ena, CD19, ndipo ndi mankhwala amphamvu kwambiri. Onsewa ndi othandiza pakuchepetsa ma cell a B m'magazi, koma ma cell a CD19 omwe amawongolera amatha kufikira ma cell a B omwe amakhala m'matishu m'njira yomwe ma antibody therapy sangathe, adatero Konig.