Nkhani

Kafukufuku waposachedwa akuwonetsa kugwira ntchito kwa CD7 CAR-T therapy yotsatiridwa ndi yachiwiri ya allogeneic hematopoietic stem cell transplantation (HSCT) mwa odwala omwe adayambiranso T-cell acute lymphoblastic leukemia (T-ALL) ndi lymphoblastic lymphoma (LBL), zomwe zikuwonetsa kuthekera kwakukulu mu kukwaniritsa zochepa zotsalira matenda (MRD) -negative chikhululukiro chonse.

Kafukufuku wochititsa chidwi akuwonetsa kupambana kwanthawi yayitali kwa CD19 CAR T-cell therapy pochiza odwala omwe ali ndi relapsed/refractory acute lymphoblastic leukemia (ALL) kutsatira allogeneic hematopoietic stem cell transplantation, kupereka chiyembekezo chatsopano mu hematology.

Bioocus ali patsogolo pakupanga njira zochiritsira za CAR-T za m'badwo wotsatira. Buku laposachedwapa la Dr. Chunrong Tong ndi gulu lake ku Lu Daopei Hospital likuwonetsa kupita patsogolo kwakukulu ndi zovuta pakugwiritsa ntchito mankhwala a CD19 CAR-T a m'badwo wachiwiri kwa odwala a ana, kusonyeza kudzipereka kwa Bioocus ku chithandizo chamankhwala cha khansa.

Kafukufuku wochititsa chidwi akuwonetsa mphamvu yodabwitsa ya CAR-T cell therapy pochiza B-cell Acute Lymphoblastic Leukemia (B-ALL). Kafukufukuyu, wophatikizana ndi BIOOCUS ndi Chipatala cha Lu Daopei, akuwonetsa kupita patsogolo kwakukulu, ndikukhazikitsa chithandizo ngati njira yofunika kwambiri yothandizira.

Ofufuza ochokera ku Chipatala cha Lu Daopei ndi ogwira nawo ntchito padziko lonse lapansi amafufuza njira zochiritsira zama cell za CAR-T, zomwe zimapereka chiyembekezo kwa odwala omwe ali ndi matenda a B cell. Kafukufukuyu akuwunikira kupita patsogolo kwapangidwe ndi kagwiritsidwe ntchito, kuwonetsa zotsatira zabwino komanso kuthekera kwazatsopano zamtsogolo.

Kafukufuku waposachedwa wa zachipatala akuwonetsa kuti ma cell a CD19 CAR-T okhala ndi 4-1BB amawonetsa mphamvu zothana ndi zotupa poyerekeza ndi ma CD28-based CAR-T cell pochiza B cell acute lymphoblastic leukemia (r/r B-ALL).

Kafukufuku waposachedwa pa chipatala cha Lu Daopei adawonetsa mphamvu komanso chitetezo chokwanira cha CD19 CAR-T cell therapy pochiza odwala omwe ali ndi refractory kapena kubwereranso kwa B acute lymphoblastic leukemia (B-ALL). Kafukufuku, omwe adaphatikizapo odwala 51, adawonetsa kukhululukidwa kwathunthu ndi zotsatira zochepa.

Chipatala cha Lu Daopei ndi Hebei Senlang Biotechnology alengeza zomwe apeza kuchokera ku kafukufuku wawo waposachedwa wokhudza chitetezo ndi mphamvu ya chithandizo cha CAR-T cha acute B cell leukemia. Kugwirizana kumeneku kukuwonetsa kuthekera kwa mapangidwe a cell a CAR-T kuti apititse patsogolo zotsatira za odwala.

Kafukufuku watsopano wotsogoleredwa ndi Dr. Zhi-tao Ying wochokera ku Peking University Cancer Hospital wasonyeza chitetezo ndi mphamvu ya IM19 CAR-T cell therapy pochiza matenda obwerera m'mbuyo komanso otsutsa a B-cell hematologic. Lofalitsidwa muChinese Journal of New Drugs, phunziroli likuwonetsa kuti 11 mwa odwala 12 adalandira chikhululukiro chathunthu popanda zotsatirapo zoipa, kusonyeza kuthekera kwa IM19 ngati njira yodalirika yothandizira odwala omwe ali ndi njira zina zochepa.

Pazaka makumi asanu zapitazi, kafukufuku wa ma cell a Natural Killer (NK) asintha kamvedwe kathu ka chitetezo cham'thupi, ndikupereka njira zatsopano zochizira khansa ndi ma virus.

Maphunziro a pachaka a 2024 a Clinical Blood Management and Transfusion Technology ku Sanhe City adachitika bwino pachipatala cha Yanda Ludaopei. Chochitikachi chikufuna kupititsa patsogolo kasamalidwe ka magazi ndi chitetezo cha kuikidwa magazi kudzera m'magawo ophunzitsidwa bwino omwe amapezeka ndi akatswiri a zaumoyo oposa 100 ochokera m'mabungwe osiyanasiyana azachipatala.

Kafukufuku wochita upainiya pachipatala cha Erlangen University Hospital anathandiza bwino mtsikana wazaka 16 yemwe ali ndi systemic lupus erythematosus (SLE) yoopsa pogwiritsa ntchito CAR-T cell therapy. Uku ndiko kugwiritsa ntchito koyamba kwa mankhwalawa kwa ana a lupus, kupereka chiyembekezo chatsopano kwa ana omwe ali ndi matenda a autoimmune.