Myasthenia gravis-02

Li Ming's Myasthenia Gravis Chithandizo Nkhani

Li Ming, mphunzitsi wazaka 35, adayamba kukumana ndi zizindikiro za myasthenia gravis (MG) zaka zitatu zapitazo. Poyamba, anaona ptosis (kugwedera zikope) ndi kuvutika kulankhula, koma zizindikiro pang'onopang'ono zinakula mpaka kufooka kwa minofu, kupangitsa ngakhale zochita za tsiku ndi tsiku kukhala zovuta. Ngakhale kuti ankalandira mankhwala osiyanasiyana, kuphatikizapo ma steroids ndi ma immunosuppressants, zizindikiro zake sizinali zolamulirika.

Kudzera m'mawu a bwenzi lake, a Li Ming adafika pachipatala cha Lu Daopei kuti achite nawo mayeso azachipatala a CAR-T. Gulu la akatswiri linapenda mwatsatanetsatane zizindikiro zake ndi kumukonzekeretsa chithandizo cha CAR-T.

Njira Yochizira:

1. Gawo Lokonzekera: Asanalandire chithandizo, Li Ming adawunikiridwa mokwanira zaumoyo. Madokotala analekanitsa ma T cell m'thupi lake ndikusintha ma genetic mu labotale kuti afotokozere chimeric antigen receptors (CAR) kulunjika ma antigen enieni okhudzana ndi myasthenia gravis.

2. Kukula kwa Maselo: Maselo osinthidwa a CAR-T anakulitsidwa mu labotale kuti atsimikizire kuti chiwerengero chokwanira cha mankhwala.

3. Preconditioning Chemotherapy: Asanayambe kulowetsedwa kwa selo la CAR-T, Li Ming adalandira chithandizo chamankhwala cha chemotherapy kwa sabata kuti achepetse chiwerengero cha ma lymphocyte omwe alipo m'thupi lake, kupanga malo abwino kuti maselo a CAR-T azigwira ntchito bwino.

4. Kulowetsedwa kwa Maselo a CAR-T: Atamaliza chemotherapy, Li Ming anagonekedwa m'chipatala kuti alandire kulowetsedwa kwa selo la CAR-T. Njirayi inkachitidwa pansi pa kuyang'anitsitsa kwambiri kuti tipewe zotsatirapo.

Zotsatira za Chithandizo:

1. Kuyankha Kwakanthawi kochepa: M'sabata yoyamba pambuyo pa kulowetsedwa, Li Ming adakumana ndi kutentha thupi pang'ono ndi kutopa, zomwe zimachitika kwakanthawi kochepa ku chithandizo cha cell cha CAR-T. Patapita milungu iwiri, ptosis yake ndi kuvutika kulankhula bwino kwambiri, ndipo mphamvu zake zinayamba kubwerera.

2. Kupititsa patsogolo Pakatikati: Patadutsa miyezi iwiri, zizindikiro za Li Ming zinali zitachepa kwambiri. Anatha kuyambiranso ntchito zanthawi zonse zophunzitsira, ntchito yake idayenda bwino, ndipo moyo wake udawonetsa kuwongolera kwakukulu.

3. Zotsatira Zakale: Miyezi itatu pambuyo pa chithandizo, Li Ming sanadalirenso mankhwala am'mbuyomu. Kafukufuku wotsatira adawonetsa kuti chitetezo chake cha mthupi chinali bwino, popanda zotsatirapo zoyipa zomwe zidawonedwa.

Kudzera mu chithandizo cha ma cell a CAR-T, Li Ming's myasthenia gravis idayendetsedwa kwambiri. "Ndili wokondwa kwambiri chifukwa cha chithandizo cha CAR-T komanso gulu lachipatala lodzipereka chifukwa cha kuyesetsa kwawo," a Li Ming anatero akulira, akugwira dzanja la dokotala atatuluka.