Myasthenia gravis-01

Nkhani ya Chithandizo cha Myasthenia Gravis ya Zhang Wei

Zhang Wei, wopanga mapulogalamu azaka 32, adayamba kukumana ndi zizindikiro za myasthenia gravis (MG) zaka ziwiri zapitazo. Poyamba, anali ndi ptosis (zikope zogwa) ndi kusawona bwino, koma zizindikiro zake zinakula kwambiri pakapita nthawi, zomwe zinapangitsa kufooka kwa minofu komwe kunakhudza kwambiri ntchito yake ndi moyo wa tsiku ndi tsiku. Ngakhale kuti ankalandira chithandizo chamankhwala chosiyanasiyana, kuphatikizapo mankhwala oletsa anticholinesterase, mankhwala oletsa chitetezo cha m’thupi, ndi kuloŵetsa m’mitsempha ya immunoglobulin, zizindikiro zake zinapitirizabe ndipo nthaŵi zambiri zinkabwerera.

Ndi njira zochiritsira zachikhalidwe zomwe zikuoneka kuti sizikugwira ntchito, madokotala ananena kuti Zhang Wei ayese njira yatsopano yochizira: CAR-T cell therapy. Thandizo lamakonoli limagwiritsa ntchito uinjiniya wa majini kuti asinthe maselo a T a wodwalayo, kuwapangitsa kulunjika ndikuchotsa ma cell achilendo okhudzana ndi matendawa.

Pambuyo pakuwunika bwino, Zhang Wei adawonedwa kuti ndi woyenera kulandira chithandizocho. Madokotala poyamba anapatula maselo a T m'thupi lake ndikusintha chibadwa ndi kuwakulitsa mu labotale. Zhang Wei ndiye adalandira chithandizo chamankhwala kuti achepetse kuchuluka kwa ma lymphocyte omwe alipo m'thupi lake, kukonzekera kukhazikitsidwa kwa maselo a CAR-T. Pomaliza, maselo osinthidwa a CAR-T adabwezeredwa m'thupi la Zhang Wei.

Pa gawo loyambirira la chithandizo, Zhang Wei adatopa pang'ono, koma patatha milungu iwiri, zizindikiro zake zidayamba kuyenda bwino. Ptosis ndi kusawona bwino zidachepetsedwa, ndipo mphamvu zake zidabwerera pang'onopang'ono. Patatha mwezi umodzi, ntchito yake inayenda bwino, ndipo anatha kuyambiranso zochita za tsiku ndi tsiku. Miyezi itatu atalandira chithandizo, zizindikiro za Zhang Wei zinali zitangotsala pang'ono kutha, ndipo sanafunenso mankhwala am'mbuyomu. Kufufuza kotsatira kunasonyeza kuti chitetezo chake cha mthupi chinali bwino, popanda zotsatirapo zoipa kapena zizindikiro za kubwereranso kwa matenda.

Kupyolera mu chithandizo cha ma cell a CAR-T, Zhang Wei's myasthenia gravis inkawongoleredwa kwambiri, kupititsa patsogolo moyo wake komanso kuthekera kwake pantchito. Chithandizochi chimapereka chiyembekezo chatsopano kwa odwala ambiri a myasthenia gravis.