Multiple Myeloma(MM)-02

Wodwala Wa ku Italy Akufuna Chithandizo Ndipo Anachiritsidwa Ku Multiple Myeloma ndi CAR-T Therapy

Cinty, mayi wazaka 66, adapezeka kuti ali ndi lambda light chain multiple myeloma, ISS stage I, ku Italy mu October 2018. peripheral neuropathy. Pofunafuna chithandizo chogwira ntchito, adasinthidwa ma cell awiri a autologous stem cell mu Meyi 2019 ndi Novembala 2019, kukhululukidwa kwathunthu, ndipo adasungidwa pakamwa lenalidomide.

Komabe, mu Ogasiti 2020, kuwunika kotsatira kwa PET/CT kunawonetsa kuwonongeka kwa mafupa atsopano komanso kuwonjezeka kwachangu kwa maunyolo owunikira opanda seramu. Kufufuza kwa mafupa a m'mafupa kumasonyeza kukula kwa matenda, ndipo kuyezetsa kwa FISH kunasonyeza kusayenerera kwatsopano kwa cytogenetic: t (11; 14). Pambuyo pa ma 4 a DVD regimen chemotherapy kuyambira Seputembara 2020, matenda ake anali osalamulirika ndipo amapitilira patsogolo. Ngakhale kuti anasintha maulendo a 3 a PCd regimen, ululu wake wa mafupa unapitirirabe ndipo edema ya m'munsi mwa miyendo inakula kwambiri. Atatopa ndi chithandizo chamankhwala chodziwika bwino padziko lonse lapansi komanso kusinthidwa kawiri, adayamba kukana mankhwala angapo.

Ataphunzira za kufunikira kwa mayeso achipatala a CAR-T pachipatala cha Ludaopei kudzera pa intaneti, adafunsira visa ndipo adafika ku China mu Marichi 2021. Atatha mwezi wokhala yekhayekha, adagonekedwa ku chipatala cha Yanda Ludaopei pa Epulo 22. 2021. Pambuyo pa mayeso angapo ndi kuwunika kwa matenda, adalandira kulowetsedwa kwa ma cell a BCMA CAR-T pambuyo pa FC chemotherapy preconditioning mu Meyi chaka chomwecho. Pambuyo pa kulowetsedwa, zizindikiro zake zofunika zinali zokhazikika, ndipo sanakumane ndi zotsatirapo zoyipa kupatula kutentha thupi pang'ono. Edema ya m'munsi mwa miyendo yake inatha pang'onopang'ono, ndipo anasangalala kuona kuti thanzi lake likuyenda bwino.

Mwezi umodzi pambuyo pa kulowetsedwa kwa CAR-T, zotsatira za mayeso a Cinty zinasonyeza: 24-ola 24 protein protein quantification pa 50 mg / tsiku, yochepetsedwa kwambiri kuchokera kumagulu ovomerezeka; unyolo wa seramu wopanda kuwala: FLC-κ pa 4.58 mg/L ndi FLC-λ pa 0.61 mg/L; ndipo kuwunika kwamafuta a m'mafupa sikunawonetse maselo ofunikira a plasma. Anamuyeza kuti ali mu kukhululukidwa kwathunthu (CR).

Panopa, miyezi isanu ndi itatu atabwerera ku Italy, ululu wamsana wa Cinty ndi edema ya m'munsi mwa miyendo iwiri yatha, ndipo ali wathanzi. Kuchokera pamtunda wamakilomita masauzande ambiri, Cinty adathokoza kwambiri gulu lachipatala cha Yanda Ludaopei ndi Director Zhang Xian.

Milandu iwiri yachipatalayi yochokera ku chipatala cha Ludaopei ikuwonetsa kuti ngakhale odwala omwe ali ndi BCMA yotsika kapena osalankhula mu myeloma angapo amatha kuchita bwino ndi BCMA CAR-T cell therapy. Izi zikuyimira kupambana kwa chithandizo cha CAR-T cha myeloma yambiri, kubweretsa chiyembekezo chatsopano kwa odwala omwe ali ndi vuto lapamwamba la maselo a plasma ndi myeloma yambiri.