Junaid----Acute B-lymphocytic Leukemia (B-ALL)

Kuyesedwa kwachipatala kwa CAR-T mlatho kuyika mafupa kumapangitsa kuti odwala B-ALL akhale opanda matenda pachipatala cha Lu Daopei.

Zaka zisanu zapitazo, Junaid anali wophunzira ku Pakistan Medical University, wodzaza ndi zokhumba zokhala dokotala. Koma mu May 2014, anamupeza ndi acute B-lymphocytic leukemia ndipo anasiya maphunziro ake.

Anathandizidwa m’derali kwa zaka zoposa ziwiri. Mu Januwale 2018, adayambanso kupweteka kwa mafupa a systemic ndipo mayeso a mafupa adawonetsa kuti wayambiranso. Pambuyo pa njira yachiwiri ya mankhwala amphamvu pachipatala chapafupi, sanathe kupeza chigonjetso ndipo matendawa anali atakula. Kupyolera mu kufufuza kwa intaneti ndi malingaliro a odwala ena, adaganiza zobwera kuchipatala cha Lu Daopei kuti akayesedwe kachipatala ka CART ndi BMT.

Pa 26 Marichi 2018, Junaid ndi banja lake adabwera ku China ndipo adagonekedwa ku dipatimenti yayikulu ya hematology pachipatala cha Lu Daopei. Dr Peggy Lu ndi Dr Junfang Yang adawunikiranso za Junaid. Malipotiwo adawonetsa kuti kuphulika kwa m'mafupa kunali kokwera mpaka 69% ndipo anali ndi matenda oyamba ndi fungus. Atalandira chithandizo mosamala, wodwalayo anali mumkhalidwe wokhazikika. Pa 24 Epulo 2018, Junaid adalowetsedwanso ndi ma CD19 & CD22 CAR-T. Patatha milungu iwiri, kuchuluka kwa maselo a m'mafupa a mafupa kunali 0. Kumwetulira kunabwerera ku banja la Junaid. Junaid adayenera kuchita BMT kuti akhale wopanda matenda.

Pa 25 June 2018, Dr Yue Lu, mkulu wa dipatimenti ya BMT, ndi gulu lachipatala la Dr Fang Xu adachita BMT kwa Junaid. Wopereka kwa Junaid ndi mng'ono wake. pa Julayi 6, cell cell stem cell idalowetsedwanso ku Junaid, patatha masiku 17 kuyika maselo oyera a magazi kunamalizidwa ndipo adachoka mu wodi yotulutsa laminar. Pakatha masiku 24, mtundu wake wa m'mafupa umagwirizana kwathunthu ndi fupa la woperekayo. Kuwunikiridwa kwa lipoti lotsalira la mafupa ndikolakwika, popanda zovuta zoyambilira zokhudzana ndi kumuika. Pa 6 Ogasiti 2018, Junaid adatulutsidwa m'chipatala ndipo adayamba kutsatira odwala.

Gulu la magazi achi China ndi chithandizo cholimba cha wodwalayo Junaid ndi mtundu wamagazi wa RH, womwe ndi mtundu wosowa wamagazi. Anavomera "Lang Fang rare blood type alliance" kupereka magazi kwaulere kwanthawi zambiri panthawi yomwe adagonekedwa m'chipatala. Sizikuwoneka ngati kuchepa kwa kulowetsedwa kwa magazi kwa iye, Junaid ndi banja lake amayamikira kwambiri likulu lapadziko lonse lapansi pochita zonsezi kwa Junaid. Panthawiyi, ogwira ntchito ku likulu la mayiko anatsagana ndi Junaid ndi banja lake kuchokera pamene anafika mpaka pano, anawathandiza pamoyo wawo wonse ndipo anathandiza banjalo kuthana ndi vuto la chinenero.

Mayesero azachipatala a CAR-T amalumikiza BMT kuti apange chozizwitsa china. Dipatimenti ya BMT ya Chipatala cha Lu Daopei ndi amodzi mwamalo omwe amagwira ntchito kwambiri ku BMT padziko lonse lapansi. Junaid ndi wachiwiri wodwala matenda a khansa ya m'magazi a B-lymphocytic leukemia wachiwiri ku Pakistan kulandira chithandizo cha CAR-T Bridge BMT. Kutulutsa bwino kwa Junaid m'chipatala kukuwonetsanso kuzindikirika kwapadziko lonse kwaukadaulo wapamwamba wachipatala chathu wa CAR-T bridge transplantation.