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Zogulitsa Magulu
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Innovative Gene Therapy Imapereka Chiyembekezo Chatsopano kwa Odwala Sickle Cell ndi Thalassemia

Innovative Gene Therapy Imapereka Chiyembekezo Chatsopano kwa Odwala Sickle Cell ndi Thalassemia
FUCASO: Therapy ya Revolutionary Fully-Human BCMA CAR-T yokhala ndi Kuchita bwino komanso Chitetezo

FUCASO: Therapy ya Revolutionary Fully-Human BCMA CAR-T yokhala ndi Kuchita bwino komanso Chitetezo
Kuvulala kwa Mitsempha ya Optic-03

Kuvulala kwa Mitsempha ya Optic-03
Kuvulala kwa Mitsempha ya Optic-02

Kuvulala kwa Mitsempha ya Optic-02
Kuvulala kwa Mitsempha ya Optic-01

Kuvulala kwa Mitsempha ya Optic-01
Metastatic melanoma-04

Metastatic melanoma-04
Khansara ya m'mawere-03

Khansara ya m'mawere-03
Ocular melanoma (poyamba), yotsatiridwa ndi zotupa za chiwindi za metastatic-02

Ocular melanoma (poyamba), yotsatiridwa ndi zotupa za chiwindi za metastatic-02
Advanced stage IV colorectal cancer-01

Gawo la IV colorectal cancer-01
Khansara ya prostate yapamwamba kwambiri yomwe imatsagana ndi mafupa angapo a metastases-05

Khansara ya prostate yapamwamba kwambiri yomwe imatsagana ndi mafupa angapo a metastases-05
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FUCASO: Therapy ya Revolutionary Fully-Human BCMA CAR-T yokhala ndi Kuchita bwino komanso Chitetezo

FUCASO ndi njira yosinthira ya BCMA yolunjika ku CAR-T yopangidwa ndi IASO BIO, yopereka mphamvu zosayerekezeka ndi chitetezo pakubwerera m'mbuyo kapena refractory angapo myeloma. Ndi mayankhidwe apamwamba, kukhululukidwa kolimba, ndi mbiri yachitetezo champhamvu, FUCASO imapereka chiyembekezo chatsopano kwa odwala ndikukhazikitsa muyezo watsopano mu chithandizo cha CAR-T.

    Lumikizanani nafe
    tsatanetsatane wazinthu
    Ubwino waukulu wa FUCASO
    Kupambana Kwachipatala

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    FUCASO, yopangidwa ndi Nanjing IASO Biotechnology, ndi njira yochiritsira ya CAR-T yopangidwa makamaka kuti igwirizane ndi B-cell maturation antigen (BCMA). Thandizoli limadziwika chifukwa cha mphamvu zake zosayerekezeka zachipatala komanso mbiri yachitetezo, zomwe zimapereka chiyembekezo chatsopano kwa odwala omwe abwereranso kapena kukana multipleeloma (r/rMM). Yavomerezedwa ndi National Medical Products Administration (NMPA) pa Juni 30, 2023, FUCASO yawonetsa kale kupambana kwakukulu pamagwiritsidwe azachipatala.

    Mayankho Okwera Kwambiri: FUCASO imadzitamandira ndi Mlingo Wonse Woyankha (ORR) wa 98.9% ndi Mlingo Wathunthu Woyankha (CR) wa 82.4%, wapamwamba kwambiri kuposa mankhwala ena omwe alipo.

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    Chikhululukiro Chokhazikika: Odwala omwe amathandizidwa ndi FUCASO awonetsa mwezi wa 12 Progression-Free Survival (PFS) mlingo wa 85.5%, kusonyeza kukhululukidwa kwa nthawi yaitali ndi kupititsa patsogolo moyo wabwino.

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    Mbiri Yachitetezo: Ndi ≥3 grade Cytokine Release Syndrome (CRS) yomwe imapezeka mwa odwala 1% okha ndipo palibe milandu ya ≥3 grade Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), FUCASO imapereka njira yochiritsira yotetezeka poyerekeza ndi machiritso ena a CAR-T .

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    Mtengo-Kuchita bwino: Kuchiza kwa FUCASO kumawononga ndalama zochepa kwambiri poyerekeza ndi njira zochiritsira zofanana zomwe zimapezeka ku United States, zomwe zimapangitsa kuti ikhale njira yabwino kwa odwala ambiri.

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    Kufikira Padziko Lonse: IASO Bio yakhazikitsa malo opangira chithandizo chamankhwala ku China, omwe amatha kuthandiza odwala padziko lonse lapansi ndi mautumiki ophatikizika kuyambira pakukambirana mpaka kusamalidwa pambuyo pa chithandizo.

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    Wodwala woyamba kuthandizidwa ndi FUCASO wakwanitsa zaka zisanu kuti apulumuke popanda khansa, chinthu chofunikira kwambiri poyerekeza ndi Progression-Free Survival (PFS) ya miyezi 2.9 yokha ndi chisamaliro chokhazikika. Izi zikuwonetsa kuthekera kwa FUCASO kuti asinthe mawonekedwe amankhwala a myeloma angapo.

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