Kufalitsa Large B-cell Lymphoma (DLBCL)

Wodwalayo, mayi wolimba mtima amene watsala pang’ono kukwanitsa zaka 80, molimba mtima anakumana ndi matenda a Diffuse Large B-cell Lymphoma (DLBCL), kusonyeza kulimba mtima kwakukulu pankhondo yake yolimbana ndi khansa yoopsa imeneyi.

Ngakhale kuti anali wokalamba, iye anapitirizabe kulimbana ndi mavuto amene anakumana nawo chifukwa cha matenda ake. Komabe, pasanathe miyezi isanu ndi umodzi atalandira chikhululukiro ndi chithandizo chamankhwala choyamba, anayambiranso, zomwe zinasonyeza kuopsa kwa matenda ake. Ngakhale adayesa kangapo ndi chithandizo chachiwiri ndi chachitatu, khansa yake idawonetsa kukana, zomwe zidabweretsa vuto lalikulu kwa gulu lake lachipatala.

Pozindikira kufulumira kwa vuto lake, gulu lachipatala linayamba kufufuza njira zina zochiritsira. Wodwalayo adalembetsedwa ku mayeso azachipatala ofufuza za CD19 + 22 CAR-T cell therapy, njira yopitilira muyeso yomwe imagwiritsa ntchito ma cell opangidwa ndi chibadwa cha T kulunjika ma cell a khansa omwe amawonetsa ma antigen enieni.

Zotsatira zake sizinali zachilendo. Patangotha ​​mwezi umodzi kulowetsedwa kwa maselo a CD19+22 CAR-T, wodwalayo adakhululukidwa kwathunthu. Zotsatira zoyipazi sizinangoyimitsa kupitilira kwa matenda ake komanso zidapangitsa kuti ma cell a khansa athetsedwe bwino, zomwe zidakhala nthawi yofunikira kwambiri paulendo wake wamankhwala.

Panthawi yonse yovutayi, gulu lachipatala linapereka chithandizo chosagwedezeka ndi chisamaliro kwa wodwalayo. Kuchokera pakuyang'anitsitsa momwe amayankhira chithandizo mpaka kuyang'anira zochitika zilizonse zovuta, adatsimikizira kuti ubwino wake ukhalabe wofunika kwambiri.

Poganizira zimene zinamuchitikira, wodwalayo anayamikira kwambiri chithandizo chachifundo chimene analandira. "Kudzipereka komanso ukadaulo wa gulu langa lachipatala zinali zachilendo," adatero. "Njira yawo ya chithandizo chaumwini inandipatsa chiyembekezo pamene ndimafunikira kwambiri."

Zotsatira zabwino za CD19 + 22 CAR-T cell therapy pokwaniritsa kukhululukidwa kwathunthu zikuwonetsa kuthekera kwake ngati njira yodalirika yothandizira odwala omwe amakana DLBCL. Mlanduwu ndi umboni wa mphamvu zochiritsira zatsopano komanso mankhwala opangidwa ndi munthu payekha pakuwongolera khansa zovuta, makamaka mwa odwala okalamba ngati mayi wolimba mtima uyu.

Pamaso & 1 mwezi pambuyo kulowetsedwa