Kufalitsa B-cell lymphoma (DBCL), NOS, GCB subtype, primary central nervous system lymphoma-01

Mu Disembala 2019, Bambo Wang, mphunzitsi waku Northeast China, adayamba kudwala mutu. Pa Disembala 19, 2019, kuyezetsa matenda kudawulula izi: PET-CT idawonetsa mthunzi wosalimba womwe ukuchulukirachulukira kagayidwe ka FDG kumbali yakumanzere yakumanzere ndi bondo la corpus callosum (pafupifupi 3.4 * 1.9 cm, SUVmax = 34.4). Biopsy ndi immunohistochemistry anatsimikizira kufalitsa lalikulu B-cell lymphoma (DLBCL, NOS, GCB subtype), ndi immunophenotype kusonyeza Ki67(50%+), CD19(+), CD20(+), PAX5(+), CD79(+), MUM1(+), BCL(+), CD10(-/+), CD2(minor+). Kusanthula kwamadzi am'magazi kunawonetsa 6% ma cell a lymphoid osakhwima omwe ali ndi kusintha kwa morphological. Matendawa anali oyambirira pakati pa mitsempha ya mitsempha ya lymphoma (DBCL, GCB subtype).

Atafufuza njira zamankhwala pa intaneti, Bambo Wang adaphunzira za Lu Dao Pei Hospital's immunotherapy mphamvu ndipo nthawi yomweyo adafunafuna ukatswiri wawo. Pambuyo pofufuza bwinobwino thupi ndi kusanthula mosamala ndi gulu la akatswiri a chipatala, adaganiza kuti Bambo Wang atenge nawo mbali mu mayesero a zachipatala a CART therapy, makamaka pogwiritsa ntchito CD19 CART cell. Analandira kulowetsedwa kwa cell CD19 CAR-T autologous pa Epulo 24, 2023. Pofika pa Julayi 30, 2023, adayesedwa kuti adakhululukidwa (CR) ndipo wabwerera ku moyo wabwinobwino.