Kufalitsa B-cell lymphoma (DLBCL) -04

Bambo Li, wazaka 64 (dzina lachinyengo), adapezeka ndi B-cell lymphoma (DLBCL) zaka zinayi zapitazo, zomwe zidapita patsogolo mpaka kumapeto kwa ndulu, nthiti, mapapo, ndi pleura, zomwe zimatchedwa siteji IV. . Kutsatira immunochemotherapy woyamba, matenda ake adakhululukidwa kwa zaka zitatu. Komabe, mu Marichi chaka chatha, matenda ake adayambiranso, kuphatikiza ma lymph nodes angapo a retroperitoneal. Ngakhale kuti chithandizo chamankhwala chachiwiri cha salvage chemotherapy, iye anangopindula pang'ono ndipo anawonongeka mofulumira, zomwe zinafunika chithandizo chamankhwala chothandizira kuti apitirizebe kupita patsogolo.

Poyang'anizana ndi vuto lalikululi, gulu la akatswiri pachipatala cha Lu Daopei linapenda mozama nkhani ya Bambo Li ndipo inaitanitsa msonkhano wamagulu osiyanasiyana (MDT) kuti avomereze chithandizo cha CAR-T cell. CAR-T cell therapy, monga mtundu waposachedwa kwambiri wa tumor immunotherapy, imapereka zabwino zambiri monga kulunjika mwamphamvu komanso kupirira kwa odwala omwe abwerera m'mbuyo komanso refractory lymphoma.

Mu Januwale 2023, Bambo Li adalandira chithandizo cha cell cha CAR-T ku dipatimenti ya Lymphoma. Asanalandire chithandizo, adachitidwa opaleshoni ya ma lymph nodes oyenerera, omwe adatsimikizira kuti CD19 ndi CD20 positivity, ndikupereka zolinga zomveka bwino za CAR-T cell therapy. Motsogozedwa ndi Pulofesa Li, gulu lachipatala linapanga dongosolo lachithandizo laumwini.

Pa Julayi 25, 2023, Bambo Li adamaliza kulowetsedwa kwa ma CD19/20 CAR-T cell, omwe adayenda bwino akuyang'aniridwa mosamala ndi gulu lachipatala. Ngakhale atakhala ndi cytokine release syndrome, cytopenia, ndi chiopsezo chotenga matenda pambuyo pa kulowetsedwa, chisamaliro chokhazikika chothandizira chinatha kuthetsa zowawa panthawi ya chithandizo.

Patangotha ​​​​miyezi isanu ndi umodzi atagwiritsa ntchito chithandizo cha cell cha CAR-T, Bambo Li sanawonetsere zotupa zazikulu m'thupi lake, kukwaniritsa mayankho athunthu a metabolism (CMR), zomwe zidabweretsa chiyembekezo chatsopano cha thanzi lake. Gulu lachipatala linawonjezeranso zotsalira zotsalira za retroperitoneal ndi radiotherapy kuti zitsimikizidwe kuti matenda atha kukhazikika komanso kukhazikika kwanthawi yayitali.

Kupyolera mu CAR-T cell immunotherapy iyi, Bambo Li sanangopindula kwambiri mu mkhalidwe wake komanso adapezanso chidaliro ndi nyonga m'moyo. Mlandu wake umapereka chiyembekezo chatsopano komanso chitsogozo kwa odwala omwe ali ndi lymphoma komanso kuwonetsa kuthekera komanso mphamvu ya CAR-T cell therapy pochiza refractory lymphoma.

CAR-T cell therapy, ngati njira yochiritsira khansa, ikusintha moyo wa odwala omwe ali ndi refractory lymphoma. Poyang'aniridwa mosamala ndi gulu la akatswiri ku Dipatimenti ya Lymphoma, odwala ambiri monga Bambo Li akhoza kuyembekezera kusintha kwakukulu pakukhala ndi moyo wabwino. Kuyang'ana m'tsogolo, kupita patsogolo kwina ndikugwiritsa ntchito kwa CAR-T cell therapy kumalonjeza chiyembekezo chochulukirapo komanso mwayi wochiza khansa.