Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Zabwino! Wodwala wochokera ku Norway, Bjørn Simensen, yemwe ali ndi zaka ziwiri zachikhululukiro chokhazikika.

Mnyamata wazaka 67 Bjørn Simensen adaperekedwa kuchipatala mu September 2017 ndi madandaulo a chifuwa ndi kupweteka pachifuwa. Pantchito yake, adapezeka kuti ali ndi myeloma yambiri (IgG lambda) ISS-II. Wodwalayo adalandira maulendo a 4 a bortezomib, lenalidomide ndi dexamethasone chemotherapy. Pambuyo pa mizungu 4 mapuloteni ake a M anali osakwana 1g/l. Wodwalayo adatuluka kukonzanso lenalidomide (masabata a 10mg qdx3 pamwezi m) zomwe adapitilira zaka 2 zotsatira. Anakhalabe wopanda matenda mpaka chilimwe cha 2021 pomwe pakuwunika kukhululukidwa adapezeka kuti adakweza mapuloteni a M (5g/l). Lenalidomide anaimitsidwa ndipo anayambika pa carfilzomib ndi daratumumab chemotherapy kuyambira October mpaka December 2021. Komabe, chemotherapy sinali yothandiza ndipo pambuyo pa chemo BM MRD inali yabwino.

Bambo Bjørn Simensen adawonedwa koyamba ku chipatala cha Lu Daopei pa 14 February 2022. BM MRD yake inawonetsa 0.25 peresenti ya maselo a plasma achilendo. IEF idawonetsa mapuloteni a IgG ndi M anali 3 g/l. PET-CT Scan inawonetsa kuchuluka kwa ma testis makamaka oyenera omwe adakulitsidwanso pakuwunika. Ma testicular biopsy adachitika omwe adawonetsa ma cell oyipa a plasma. Wodwalayo adasankhidwa kuti athandizidwe ndi ma cell a CART. Preconditioning anachitidwa ndi fludarabine ndi cyclophosphamide kwa 3 masiku. Maselo a CAR-T adalowetsedwa tsiku la 0 (4/3/2222). Mlingo woperekedwa unali 0.5X10^6/kg. Pambuyo pa kulowetsedwa, wodwala anali ndi neutropenia fever yomwe inkayendetsedwa ndi ma antibiotic a iv. Kumanja testicular kutupa pang`onopang`ono kusanduka yachibadwa kukula. Patsiku la 28 BM kuyezetsa kunali koyipa kwa ma cell a plasma. Wodwalayo adatulutsidwa ku Lu Daopei ndikutsata pafupipafupi ku hematology Center mumzinda wake.