Acute Lymphoblastic Leukemia (T-ALL) -10

Mnyamata wina wazaka 13 dzina lake Yangyang wa ku Panzhihua, m'chigawo cha Sichuan, adachitidwa opaleshoni ya CAR-T kenako ndikumuika m'mipata.

Yangyang poyamba anali ndi "mikwingwirima yomwazika m'thupi lonse limodzi ndi kutopa" pa Epulo 12, 2021. Anamupeza ndi acute lymphoblastic leukemia (T-cell subtype) yokhala ndi kukha magazi kwa intracranial ndi matenda am'mapapo omwe adatsimikiziridwa ndi kuyezetsa kwa mafupa a MICM pachipatala chachikulu. Chongqing. Analandira chithandizo cha chemotherapy katatu pachipatala china, koma mafupa sanayankhe. Pofika kumayambiriro kwa mwezi wa June, adayamba kufooka m'miyendo yonse yapansi ndipo sankatha kuyenda.

Pa Julayi 1, 2021, Yangyang adagonekedwa m'Dipatimenti yathu ya Hematology Ward 2. Adalembetsa mayeso a CD7 CAR-T pa Julayi 8 ndipo adalandira kulowetsedwa kwa cell CD7 CAR-T pa Julayi 26 kuti alandire chithandizo chamankhwala. Patatha masiku khumi ndi asanu ndi limodzi kulowetsedwa, morphology ya m'mafupa inasonyeza kukhululukidwa, ndi kutuluka kwa cytometry kumasonyeza 0.07% yokayikira zilonda zam'mimba za T lymphoblasts. Atalandira chithandizo chamankhwala, adapezanso mphamvu yoyenda paokha. Pofika tsiku la 31 pambuyo kulowetsedwa, m'mafupa ake adakhululukidwa kwathunthu.

Pakadali pano, Yangyang wasamutsidwira ku Ward 6 ya dipatimenti ya Bone Marrow Transplantation kuti akalandire chithandizo. Dr. Hai wochokera ku Ward 6 adanena kuti Yangyang wakhala akugwira ntchito mwakhama komanso ali ndi chiyembekezo panthawi yonse ya chithandizo chake. Anamuika allogeneic hematopoietic stem cell transplantation (kuchokera kwa abambo ake) pa September 28. Mikhalidwe yopangidwa ndi ogwira nawo ntchito a Dipatimenti ya Hematology kuti amuike mu bridging anayamikiridwa kwambiri.

Odwalawa, asanalembetse mayeso achipatala a CD7 CAR-T, adawonetsa zizindikiro zosiyanasiyana monga kubwereza pambuyo poikapo, T/myeloid dual expression, refractory/resistant acute T-cell leukemia, central nervous system leukemia, intracranial hemorrhage, ndi matenda a m'mapapo. Pambuyo pakuwunika ndi kulandira chithandizo ndi CD7 CAR-T, onse adakhululukidwa kwathunthu, kukwaniritsa zoyembekezeka.

Chipatala cha Ludaopei chafufuza mwachangu za chithandizo cha CAR-T ndipo chapeza zambiri pakuwongolera CRS. Kwa otenga nawo mbali ambiri, zotsatira zoyipa kwambiri zinali kutentha thupi. "Ndikhoza kukwaniritsa chikhululukiro chonse, kotero kuti malungo alibe kanthu! Ndikufuna kuti anthu ambiri adziwe kuti Ludaopei akhoza kuchita CAR-T!" adatero Yangyang waku Fujian atatuluka.