Acute Lymphoblastic Leukemia (T-ALL)-09

Wophunzira wa kuyunivesite dzina lake Mengmeng wochokera ku Yanjiao, Guizhou, adalandira chithandizo chabwino pachipatala cha Ludaopei.

Mengmeng, wamkazi, wazaka 21, adaperekedwa kuchipatala chathu pa June 22, 2021, ali ndi kutopa kosalekeza. Kuyeza kwanthawi zonse kwamagazi kunawonetsa WBC 479×10^9/L. Kufufuza kwina kwa m'mafupa kunatsimikizira acute lymphoblastic leukemia (T-cell subtype). Analandira mankhwala a chemotherapy kawiri, koma khansa ya m'magazi inakhalabe yosalabadira, ndi MRD (matenda otsalira ochepa) pa 56.01%, komanso anali ndi vuto lalikulu la khansa ya m'magazi.

Pa Ogasiti 13, ma lymphocyte a autologous adasonkhanitsidwa ndikulandila chithandizo chamankhwala. Pa Ogasiti 30, Mengmeng adalandira kulowetsedwa kwa ma cell a CD7 CAR-T. Patatha milungu iwiri kulowetsedwa, kufufuza m'mafupa kunasonyeza kukhululukidwa kwathunthu, kusasamala kwa MRD, ndi kulamulira kwapakati pa mitsempha ya mitsempha yamagazi. Anakumana ndi kalasi yoyamba ya cytokine release syndrome (CRS) popanda zosokoneza zapakati pa mitsempha.