Acute Lymphoblastic Leukemia (T-ALL)-08

Yesheng wa ku Fujian adati, "Ndikadadziwa za CAR-T ku Ludaopei, ndikadabwera kale."

Mu Seputembala 2017, Yesheng adapanga zotupa kumaso, zomwe zidafalikira pang'onopang'ono ndikuphatikizana kukhala zigamba. Pofika pa February 28, 2018, kuyezetsa m'mafupa kunatsimikizira "acute T-cell lymphoblastic leukemia" pambuyo pa maphunziro angapo a chemotherapy, ndikuwunika kwakanthawi kochepa kotsalira. Mankhwala onse adayimitsidwa mu June 2019.

Mu Meyi 2021, Yesheng adapereka anthu ambiri m'chigawo chapakamwa-pharyngeal ndikukulitsa ma lymph nodes. Kufufuzanso kwa m’mafupa kunatsimikizira kuyambiranso kotheratu kwa khansa ya m’magazi. Pa Meyi 28, Yesheng adasamutsidwa ku Dipatimenti Yachiwiri ya Hematology ku Ludaopei Hospital kuti akalandire. Pambuyo pofufuza mwatsatanetsatane, matendawa adasinthidwa kukhala "acute leukemia (T/myeloid biphenotypic)."

Kachilombo kamodzi ka mankhwala a chemotherapy sikunapangitse kuti m'mafupa mufe. Pa Julayi 27, Yesheng adalandira kulowetsedwa kwa ma CD7 CAR-T, kutsatiridwa ndi mankhwala amphamvu ophatikizana ndi autologous CD7 CAR-T cell therapy. Patatha masiku khumi ndi asanu kulowetsedwa, kufufuza kwa m'mafupa kunawonetsa matenda otsalira otsalira, ndi kalasi 1 ya cytokine release syndrome (CRS) ndipo palibe vuto lapakati pa mitsempha.