Acute Lymphoblastic Leukemia (T-ALL)-07

Mtsikana wa Miao amapeza chikhululukiro chonse atalandira chithandizo cha CAR-T atayambiranso kumuika.

Amei, wophunzira ku Hunan wa ku Miao, adasindikiza mapepala awiri a SCI. Pa Epulo 2, 2020, adagonekedwa m'chipatala chachigawo chifukwa cha kutentha thupi komwe kumachitika. Kupimidwa kwa m’mafupa kunamupeza ndi acute lymphoblastic leukemia (T-ALL). Atalandira chithandizo chamankhwala kangapo m'chipatala chakunja, m'mafupa ake sanafe. Pa Novembala 2, 2020, adamuika allogeneic hematopoietic stem cell ku chipatala chathu (mchimwene ndi mlongo, machesi a HLA 7/10). Pambuyo pa kumuika, maselo amalowetsedwa bwino, ndipo kufufuza kwa m'mafupa kumasonyeza kukhululukidwa kosalekeza.

Pa Juni 16, 2021 (miyezi 7 atamuika), kuyezetsa kokhazikika kudawonetsa kuyambiranso kwa khansa yake ya m'magazi. Pambuyo pake mankhwala amphamvu analephera kuthetsa nthendayo, ndipo anayamba kudwala chibayo ndi kachilombo ka herpes, ndi zilonda zopweteka za m’kamwa zomwe zinapangitsa kumeza kukhala kovuta. Analoledwa ku ward yachiwiri ya dipatimenti ya hematology ndipo adalembetsa mayeso achipatala a CD7 CAR-T.

Gulu lachipatala la Director Yang Junfang linapereka chithandizo chamankhwala chothana ndi matenda, kuchepetsa ululu, komanso kuyika magazi ambiri ndi mapulateleti. Chifukwa cha kuchuluka kwa chotupa (80% kuphulika m'mafupa ndi 97% kuphulika kwa magazi ozungulira), sikunali kotheka kusonkhanitsa maselo ake. Ma lymphocyte amagazi ozungulira kuchokera kwa wopereka (mchimwene wake) adasonkhanitsidwa ndikutumizidwa ku kampani yaukadaulo yazachikhalidwe cha CAR-T cell.

Pa Ogasiti 10, 2021, ma CD7 CAR-T omwe adachokera kwa anthu adabwezedwanso. Pambuyo pobwezeretsanso, maselo a CAR-T adakula mpaka 54.64% m'magazi ozungulira, ndi malungo okha komanso opanda cytokine release syndrome (CRS) kapena graft-versus-host disease (GVHD). Kufufuza kwa mafupa pa tsiku la 16 pambuyo pobwezeretsa kunasonyeza kukhululukidwa kwathunthu, ndi 54.13% maselo a CAR-T m'mafupa. Patsiku la 36, ​​fupa linapitiriza kusonyeza kukhululukidwa kosalekeza. Pakali pano, maganizo ake, kugona, ndi njala zili bwino, ndipo akuchira.