Chichewa
English French German Portuguese Spanish Russian Japanese Korean Arabic Irish Greek Turkish Italian Danish Romanian Indonesian Czech Afrikaans Swedish Polish Basque Catalan Esperanto Hindi Lao Albanian Amharic Armenian Azerbaijani Belarusian Bengali Bosnian Bulgarian Cebuano Chichewa Corsican Croatian Dutch Estonian Filipino Finnish Frisian Galician Georgian Gujarati Haitian Hausa Hawaiian Hebrew Hmong Hungarian Icelandic Igbo Javanese Kannada Kazakh Khmer Kurdish Kyrgyz Latin Latvian Lithuanian Luxembou.. Macedonian Malagasy Malay Malayalam Maltese Maori Marathi Mongolian Burmese Nepali Norwegian Pashto Persian Punjabi Serbian Sesotho Sinhala Slovak Slovenian Somali Samoan Scots Gaelic Shona Sindhi Sundanese Swahili Tajik Tamil Telugu Thai Ukrainian Urdu Uzbek Vietnamese Welsh Xhosa Yiddish Yoruba Zulu Kinyarwanda Tatar Oriya Turkmen Uyghur
Leave Your Message
Categories Categories
Nkhani Yowonetsedwa
Innovative Gene Therapy Imapereka Chiyembekezo Chatsopano kwa Odwala Sickle Cell ndi Thalassemia

Innovative Gene Therapy Imapereka Chiyembekezo Chatsopano kwa Odwala Sickle Cell ndi Thalassemia
FUCASO: Therapy ya Revolutionary Fully-Human BCMA CAR-T yokhala ndi Kuchita bwino komanso Chitetezo

FUCASO: Therapy ya Revolutionary Fully-Human BCMA CAR-T yokhala ndi Kuchita bwino komanso Chitetezo
Kuvulala kwa Mitsempha ya Optic-03

Kuvulala kwa Mitsempha ya Optic-03
Kuvulala kwa Mitsempha ya Optic-02

Kuvulala kwa Mitsempha ya Optic-02
Kuvulala kwa Mitsempha ya Optic-01

Kuvulala kwa Mitsempha ya Optic-01
Metastatic melanoma-04

Metastatic melanoma-04
Khansara ya m'mawere-03

Khansara ya m'mawere-03
Ocular melanoma (poyamba), yotsatiridwa ndi zotupa za chiwindi za metastatic-02

Ocular melanoma (poyamba), yotsatiridwa ndi zotupa za chiwindi za metastatic-02
Advanced stage IV colorectal cancer-01

Advanced stage IV colorectal cancer-01
Khansara ya prostate yapamwamba kwambiri yomwe imatsagana ndi mafupa angapo a metastases-05

Khansara ya prostate yapamwamba kwambiri yomwe imatsagana ndi mafupa angapo a metastases-05
01
4.png

Acute Lymphoblastic Leukemia (T-ALL)-06

Woleza mtima: Xiaohong

Jenda: Mwamuna

Zaka: zaka 2

Utundu: China

MatendaAcute Lymphoblastic Leukemia (T-ALL)

    Lumikizanani nafe

    Wodwala wazaka ziwiri yemwe ali ndi T-ALL amapeza chikhululukiro pambuyo pa chithandizo cha CAR-T kutsatira maulendo khumi amphamvu kwambiri a chemotherapy.


    Xiaohong wazaka ziwiri wa ku Zhejiang anapezeka ndi khansa ya m'magazi chilimwe chatha. Patatha chaka chopitilira chithandizo, cytometry yotuluka idazindikira kuyambiranso, zomwe zidapangitsa kuti banja lipite ku CAR-T immunotherapy ku Lu Daopei Hospital.


    Pa Ogasiti 9, 2020, Xiaohong adagonekedwa kuchipatala cha ana akomweko chifukwa cha "malungo amasiku atatu." Kufufuza kwa mafupa a MICM kunapezeka kuti acute lymphoblastic leukemia (T-ALL). Pambuyo pa njira imodzi ya mankhwala amphamvu, morphology ya mafupa inasonyeza kukhululukidwa kotheratu, ndipo kutuluka kwa cytometry sikunapeze maselo owopsa a msinkhu. Chithandizo champhamvu chotsatira chamankhwala pamaphunziro a 11 chinasunga kukhululukidwa kwathunthu kwa m'mafupa.


    Pa Seputembara 3, 2021, kuphulika kwa mafupa kotsatira kunawonetsa kukhululukidwa kwathunthu mu morphology, koma flow cytometry idavumbulutsa 1.85% maselo osakhwima. Pofunafuna chithandizo china, Xiaohong adaloledwa ku chipatala cha Yanda Lu Daopei pa September 24. Ataloledwa, morphology ya mafupa a mafupa anali adakali okhululukidwa, koma immunophenotyping anasonyeza 0.10% malignant immature T lymphocytes.


    Poganizira za ubwana wa Xiaohong komanso kulimbikira kwa matendawa ngakhale atalandira chithandizo chamankhwala champhamvu kwambiri chopitilira 10, gulu lachipatala la chipatala chachiwiri cha hematology laganiza kuti Xiaohong atha kulembetsa mayeso a CD7 CAR-T.


    Pa Seputembara 30, 2021, maselo am'magazi otumphukira adasonkhanitsidwa ku chikhalidwe cha ma cell a CAR-T. Pa Okutobala 10, Xiaohong adalandira FC regimen chemotherapy. Pa Okutobala 13, kuphulika kwa mafupa kunawonetsa kuphulika kochepera 5% mu morphology, ndipo kutuluka kwa cytometry kunawonetsa 0.37% ma cell owopsa osakhwima a T. Pa October 15, maselo a CD7 CAR-T anabwezeretsedwa.


    Pa Januware 3 (masiku 20 atatha kulowetsedwa), kuphulika kwa mafupa kunawonetsa kukhululukidwa kwathunthu mu morphology, popanda maselo owopsa omwe amazindikiridwa ndi cytometry yotaya. Mkhalidwe wa Xiaohong wakhazikika, ndipo wasamutsidwa kupita ku dipatimenti yomuika kuti akonzekere kumuika allogeneic hematopoietic stem cell transplant.


    Xiaohong anali ndi zaka zosakwana chaka chimodzi pamene adadwala ndikupirira mankhwala osokoneza bongo kwa chaka chimodzi. Kuwongolera bwino kwa kumuika mutalandira chithandizo cha CD7 CAR-T kwapereka chida champhamvu chogonjetsera matendawa.

    4 mm3 ku

    Kuyambira Julayi 2015, Chipatala cha Lu Daopei chayamba kuyesa kwachipatala cha CAR AT cell therapy mu matenda a magazi. Monga imodzi mwamagawo oyambilira kuti ayambitse chithandizo cha cell cha CAR-T ku China, odwala 1342 adalowa muyeso mpaka pano, ndipo zomwe zachipatala zikuwonetsa kuti ndizothandiza komanso chitetezo chokhazikika. CD7 ndi 40 kDa glycoprotein wa m'gulu la immunoglobulin superfamily, ndipo CD7 yodziwika bwino imawonetsedwa makamaka pama cell T ndi NK cell komanso kumayambiriro kwa kusiyanitsa kwa T, B ndi myeloid cell, ndipo imatha kukhala ngati cholandirira chotengera kuyanjana pakati pa T ndi B lymphocytes panthawi ya chitukuko cha lymphocyte. CD7 ndi cholembera chokhazikika pamtunda wa T cell ndipo pano ikuwunikidwa ngati chandamale chatsopano ndi CAR T cell therapy ya hematological malignancies. Posachedwapa, m'chipinda chachiwiri cha Dipatimenti ya Hematology ya Ludaopei Hospital, odwala 4 omwe ali ndi zovuta zovuta apeza zotsatira zoonekeratu pambuyo pa chithandizo cha CD7 CAR-T.

    kufotokoza2

    Fill out my online form.