Bjørn Simensen ---- Multiple Myeloma (IgG lambda) ISS-II

Ekele! Otu onye ọrịa si Norway, Bjørn Simensen, nwere afọ abụọ nke mgbaghara.

Nwa amadi Bjørn Simensen dị afọ 67 gosipụtara n'ụlọ ọgwụ na Septemba 2017 maka mkpesa nke ụkwara na mgbu obi. N'oge ọrụ ya, a chọpụtara na ọ nwere otutu myeloma (IgG lambda) ISS-II. Onye ọrịa ahụ nwetara okirikiri 4 nke bortezomib, lenalidomide na dexamethasone chemotherapy. Mgbe okirikiri 4 gachara, protein M ya erughị 1g/l. Mgbe ahụ onye ọrịa ahụ kwụsịrị nlekọta lenalidomide (10mg qdx3 izu kwa ọnwa m) na ọ gara n'ihu maka afọ 2 na-esote. Ọ nọgidere na-enweghị ọrịa ruo n'oge okpomọkụ nke 2021 mgbe n'oge ntule mgbaghara, a chọpụtara na ọ bulitela protein M (5g / l). Akwụsịrị Lenalidomide wee malite ya na carfilzomib na daratumumab chemotherapy site na Ọktoba ruo Disemba 2021. Agbanyeghị, ọgwụ ọgwụgwọ adịghị arụ ọrụ yana post-chemo BM MRD dị mma.

Bjørn Simensen bụ nke mbụ hụrụ na ụlọ ọgwụ Lu Daopei na 14 February 2022. BM MRD ya gosipụtara 0.25 pasent sel plasma na-adịghị mma. IEF gosipụtara protein IgG na M bụ 3 g/l. PET-CT Scan gosiri mmụba dị ukwuu na testis karịsịa nke ziri ezi nke amụbakwara na nyocha. A na-eme biopsy testicular nke gosipụtara mkpụrụ ndụ plasma dị njọ. A họpụtara onye ọrịa ahụ maka ọgwụgwọ cell CART. Ejiri fludarabine na cyclophosphamide mee ihe mgbochi maka ụbọchị 3. A tinyere mkpụrụ ndụ CAR-T n'ụbọchị 0 (4/3/2222). Usoro e nyere bụ 0.5X10^6 / kg. Mgbe infusion gasịrị, onye ọrịa nwere ahụ ọkụ neutropenia nke ejiri ọgwụ nje iv na-achịkwa ya. Ọzịza testicular aka nri ji nke nta nke nta na-ebelata ka ọ dị nha. N'ụbọchị 28, nyocha BM adịghị mma maka sel plasma. A chụpụrụ onye ọrịa ahụ na Lu Daopei na-esochi ya mgbe niile na ụlọ ọrụ hematology na obodo ya.