Nnukwu ọrịa leukemia Lymphoblastic (T-ALL) -07

Otu nwa agbọghọ Miao na-enweta mgbaghara zuru oke mgbe ọgwụgwọ CAR-T gasịrị na-esochi nlọghachi azụ transplant.

Amei, nwa akwụkwọ gụsịrị akwụkwọ na Hunan nke agbụrụ Miao, ebipụtala akwụkwọ SCI abụọ. N'April 2, 2020, a nabatara ya n'ụlọ ọgwụ mpaghara n'ihi ahụ ọkụ na-agaghachi. Nnyocha ụmị ọkpụkpụ chọpụtara na ọ nwere nnukwu ọrịa leukemia lymphoblastic (T-ALL). Mgbe ọtụtụ usoro ọgwụgwọ chemotherapy gasịrị na ụlọ ọgwụ dị n'èzí, ụmị ọkpụkpụ ya nọgidere na-agbaghara. Na Nọvemba 2, 2020, a na-ebugharị allogeneic hematopoietic stem cell n'ụlọọgwụ anyị (nwanne na nwanne, egwuregwu HLA 7/10). Mgbanwechara, mkpụrụ ndụ ndị ahụ gbanyere nke ọma, na nyocha ụmị ọkpụkpụ na-esochi gosipụtara mgbaghara na-adịgide adịgide.

Na June 16, 2021 (ọnwa asaa ka a tụgharịchara ya), nyocha oge niile gosipụtara nlọghachi azụ nke leukemia ya zuru oke. Usoro ọgwụgwọ chemotherapy nke sochiri ya akwụsịlighị ọrịa ahụ, ọ malitekwara ka oyi baa na nje virus herpes, na-enwe ọnya ọnụ na-egbu mgbu na-eme ka ọ sie ike ilo. A nabatara ya na ngalaba nke abụọ nke ngalaba hematology wee debanye aha na CD7 CAR-T ụlọ ọgwụ.

Òtù ahụ́ ike nke onye nduzi Yang Junfang nyere ọgwụgwọ mgbochi ọrịa na-arụsi ọrụ ike, enyemaka mgbu, na mmịnye ọbara na platelet buru ibu. N'ihi oke ibu akpụ (80% mgbawa na ụmị ọkpụkpụ na 97% gbawara n'ime ọbara), ọ gaghị ekwe omume ịnakọta mkpụrụ ndụ ya. A nakọtara lymphocytes ọbara dịpụrụ adịpụ site na onye nyere onyinye (nwanne ya nwoke) ma ziga ya na ụlọ ọrụ biotech maka omenala cell CAR-T.

Na Ọgọstụ 10, 2021, sel CD7 CAR-T ndị nyere onyinye eweghachitere. Mgbe mweghachi ya, mkpụrụ ndụ CAR-T gbasaa ruo 54.64% n'ime ọbara dị n'akụkụ, na-enwe naanị ahụ ọkụ yana enweghị nnukwu ọrịa cytokine release syndrome (CRS) ma ọ bụ ọrịa graft-versus-host (GVHD). Nyocha nke ụmị ọkpụkpụ na ụbọchị 16 post-reinfusion gosipụtara mgbagha zuru oke, yana 54.13% CAR-T cell na ụmị ọkpụkpụ. Na ụbọchị 36, ụmị ọkpụkpụ gara n'ihu na-egosi mgbaghara na-adịgide adịgide. Ugbu a, ọnọdụ uche ya, ụra na agụụ ya dị mma, ọ na-agbakekwa nke ọma.