Nnukwu ọrịa leukemia Lymphoblastic (T-ALL) -06
Onye ọrịa ụmụaka dị afọ 2 nwere T-ALL na-enweta mgbaghara mgbe ọgwụgwọ CAR-T na-esochi ihe karịrị agba iri nke chemotherapy siri ike.
Xiaohong dị afọ abụọ si Zhejiang nwere ọrịa leukemia n'oge okpomọkụ gara aga. Mgbe ihe karịrị otu afọ ọgwụgwọ gasịrị, cytometry eruba achọpụtala nlọghachi azụ, na-eduga ezinụlọ ka ha chọọ ọgwụ mgbochi ọrịa CAR-T na ụlọ ọgwụ Lu Daopei.
N'August 9, 2020, a nabatara Xiaohong n'ụlọ ọgwụ ụmụaka n'ihi "ahụ ọkụ ụbọchị atọ." Nyocha nke ụmị ọkpụkpụ MICM chọpụtara nnukwu ọrịa leukemia lymphoblastic (T-ALL). Mgbe otu usoro ọgwụgwọ chemotherapy gasịrị, mpụta ụmị ọkpụkpụ gosipụtara mgbaghara zuru oke, na cytometry eruba achọpụtara na ọ nweghị mkpụrụ ndụ akabeghị aka. Chemotherapy kpụ ọkụ n'ọnụ sochiri ihe ọmụmụ iri na otu mere ka mgbaghara nke ụmị ọkpụkpụ zuru oke.
Na Septemba 3, 2021, mwepu ụmị ọkpụkpụ na-esochi gosipụtara mgbaghara zuru oke na morphology, mana cytometry na-asọpụta kpughere 1.85% mkpụrụ ndụ akabeghị aka. N'ịchọ ọgwụgwọ ọzọ, a nabatara Xiaohong n'ụlọ ọgwụ Yanda Lu Daopei na Septemba 24. Mgbe a na-anabata ya, ọkpụkpụ ọkpụkpụ ọkpụkpụ ka na-agbaghara kpamkpam, ma immunophenotyping gosipụtara 0.10% malignant na-eto eto T lymphocytes.
N'ịtụle afọ ndụ Xiaohong na nnọgidesi ike nke ọrịa ahụ n'agbanyeghị ihe karịrị agba iri nke chemotherapy kpụ ọkụ n'ọnụ, ndị otu ahụike nọ na ngalaba nke abụọ nke ngalaba hematology kpebiri na Xiaohong nwere ike debanye aha na CD7 CAR-T ụlọ ọgwụ.
Na Septemba 30, 2021, achịkọtara mkpụrụ ndụ ọbara n'akụkụ maka ọdịbendị cell CAR-T. N'October 10, Xiaohong nwetara FC usoro ọgwụgwọ chemotherapy. N'October 13, mgbami ụmị ọkpụkpụ gosipụtara ihe na-erughị 5% mgbawa na morphology, na cytometry na-asọpụta gosiri 0.37% mkpụrụ ndụ T na-eto eto. N'October 15, eweghachiri sel CD7 CAR-T.
Na Jenụwarị 3 (ụbọchị 20 ka ọ gafechara reinfusion), ụmị ọkpụkpụ gosipụtara mgbaghara zuru oke na morphology, na-enweghị mkpụrụ ndụ akabeghị aka nke cytometry na-asọpụta achọpụtara. Ọnọdụ Xiaohong ka kwụsiri ike, ma ebugharịla ya na ngalaba ntụgharị maka ịkwadebe maka transplant cell hematopoietic allogeneic.
Xiaohong erubeghị otu afọ mgbe ọ dara ọrịa wee die ihe karịrị otu afọ ọgwụgwọ ọgwụ. Njikọ na-aga nke ọma na ntụgharị mgbe ọgwụgwọ CD7 CAR-T gasịrị enyela ngwa ọgụ dị ike iji merie ọrịa ahụ kpamkpam.
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