TIL Therapy Unveiled: Tshawb nrhiav thaj chaw ntawm Cancer Immunotherapy

TILs kev kho mob suav nrog kev tshem tawm cov qog-infiltrating lymphocytes (TILs), uas yog qhov tseeb tshaj plaws ntawm lub cev tiv thaiv kab mob qog noj ntshav hauv tus neeg mob lub cev, los ntawm cov qog thiab loj hlob lawv hauv ntau qhov chaw kuaj mob. Cov activated TILs tom qab ntawd rov muab tso rau hauv tus neeg mob lub cev los txhawb lub cev tiv thaiv kab mob lub peev xwm los tsom thiab tua cov qog nqaij hlav cancer. TILs ua haujlwm los ntawm kev lees paub cov cim tshwj xeeb ntawm cov qog nqaij hlav qog noj ntshav thiab pib lub cev tiv thaiv kab mob tiv thaiv lawv, thaum kawg ua rau qog nqaij hlav puas tsuaj.

Raws li peb cov txiaj ntsig kev kho mob, tag nrho cov txiaj ntsig ntawm TILs monotherapy nce mus txog 40%, ua rau nws txoj kev kho mob qog noj ntshav zoo tshaj plaws sib nrug los ntawm kev phais tam sim no.Biocus tailors kev kho mob dav dav rau txhua tus neeg mob. Ib lossis ob peb txoj kev kho mob yuav ua ke nrog Tils txoj kev kho, uas yuav ua rau tag nrho cov txiaj ntsig zoo rau ntau dua 80%. Cov kev kho mob ua ke yog txhawm rau txo cov qog nqaij hlav hauv lub sijhawm luv, thiab cov tils muab lub sijhawm rau tus neeg mob kom tau txais kev kho mob ntev.

High specification:qog nqaij hlav tshwj xeeb T hlwb rhiab los ntawm qog antigens, lees paub los ntawm ntau TCRs

Muaj zog tropism:Kev qhia siab ntawm chemokine receptors, muaj zog qog tropism, thiab ua haujlwm sai

Killing qog:TILs tau qhib thiab nthuav dav rau 109-1011, thiab cov qog nqaij hlav cancer seem raug tshem tawm tom qab phais

Cov nyhuv txuas ntxiv:Qhov kev faib ua feem ntawm lub cim xeeb T hlwb yog siab, thiab lawv muaj peev xwm ciaj sia nyob rau hauv lub cev tau ntev thiab raug soj ntsuam tas li

Kev nyab xeeb siab:extraction, amplification, tsis rejection cov tshuaj tiv thaiv, thiab SAE ntawm TILs hlwb los ntawm cov neeg mob lawv tus kheej

Tils txoj kev kho tau ua pov thawj zoo hauvNSCLC (non-me me cell ntsws cancer),Melanoma, mob cancer mis,Cervical Cancer,thiab Ovarian Cancer. 

Sib nrug los ntawm kev phais tshem tawm ntawm cov qog thawj, cov qog nqaij hlav qog nqaij hlav, cov qog nqaij hlav, pleural effusion, ascites, thiab lwm yam, kuj tuaj yeem sim rau kev rho tawm. Qhov kev ua tau zoo yog raws li nram no: thawj qhov mob ≥ metastatic lesion ≥ lymph nodes ≥ ascites.

Peb tus kheej tsim TILs cov txheej txheem cog qoob loo ua tiav qhov ua tiav ntawm ≥85%. Nrog rau cov ntaub so ntswg ib txwm ntawm ≥1cm3, ntau txhiab tus TIL tuaj yeem cog tau, thiab cov hlwb pom muaj zog cytotoxic. "

1.TILs yog tus neeg mob lub hlwb, yog li tsis muaj kev pheej hmoo ntawm kev tsis lees paub, ua kom muaj kev nyab xeeb siab.

2. Cov tshuaj tiv thaiv tsis zoo: Ua npaws yog tshwm sim (vim qhov tso tawm ntawm cytokines thaum TILs cell-mediated qog clearance, ua rau kub taub hau, feem ntau yuav tsum tsis muaj kev kho mob tshwj xeeb thiab daws nws tus kheej).

3.Lwm yam kev phiv tshwm sim nyob rau hauv cov kev tshawb fawb muaj xws li thrombocytopenia, febrile neutropenia, kub siab, thiab lwm yam., feem ntau yog vim TILs nyob rau hauv ua ke nrog rau lwm yam tshuaj xws li pre-kev kho mob chemotherapy (cyclophosphamide + fluorouracil), high-dose IL-2, PD-1. monoclonal antibodies, thiab lwm yam.