Lupus Erythematosus (SLE)-01

24-xyoo-laus Xiaohuan tau kawm tshuaj nyob rau hauv ib lub tsev kawm ntawv tau peb xyoos thiab tau raug mob los ntawm cov kab mob lupus erythematosus (SLE) tau ze li 10 xyoo. "Kuv tau kuaj pom thaum muaj hnub nyoog 10, thiab tus kws kho mob hais tias nws nyuaj heev los kho, Kuv tsuas yog tswj tau nws nrog tshuaj," Xiaohuan hais nrog luag nyav. Xyoo kaum xyoo dhau los, nws yuav tsum tau mus kuaj mob txhua hli thiab tshuaj noj, thiab nws tau txais kev kho tshuaj hormones, kev kho tshuaj tiv thaiv kab mob, thiab kev kho kab mob lom, tab sis tsis muaj ib qho ua tau zoo. Nws tiv taus cov plaub hau poob hnyav, ntau pob khaus, rov qab kub taub hau, thiab mob hnyav.

Tom qab ntau yam kev ntsuam xyuas ua ntej, Xiaohuan tau ntsib txhua yam kev kho mob rau CAR-T kho rau SLE. Pab pawg kws tshaj lij tau tsim cov phiaj xwm kho mob raws li nws tus mob thiab ua tib zoo npaj rau cov txheej txheem sau ntawm tes. Thaum Lub Peb Hlis 28th, kev sau cov cell mononuclear pib. Thaum lub Plaub Hlis 22nd, nws pib lymphodepleting chemotherapy. Lub Plaub Hlis 28th, cov hlwb tau rov ua dua. Nees nkaum lab CAR-hloov T hlwb tau maj mam nkag mus rau hauv Xiaohuan cov hlab ntsha, ncaj qha rau lub hlwb lupus B, pib "kev tawm tsam meej, rhuav tshem lawv ib qho los ntawm ib qho" kev sib ntaus sib tua.

Thaum Lub Rau Hli 4, 38th hnub tom qab txhaj tshuaj, Xiaohuan rov qab mus rau hauv tsev kho mob kom rov qab los. Cov txiaj ntsig kev ntsuam xyuas tau qhia tias txhua qhov ntsuas tseem ceeb tau poob mus rau qhov qub. "Kuv tsis xav tau cov tshuaj hormones lawm; nws zoo li lub neej tab tom pib," Xiaohuan hais zoo siab.