Shawn [Lub Xeem Tsis Muab]---- Mob B-lymphocytic Leukemia (B-ALL)

Kev sim tshuaj CAR-T zoo heev cawm Hong Kong B-ALL tus neeg mob.

Shawn, yog ib tug txiv neej hnub nyoog 29 xyoo los ntawm Hong Kong. Thaum Lub Peb Hlis 2017, muaj cov tsos mob ntawm kub taub hau, qaug zog thiab daj ntseg. Nws tau kuaj pom tias mob B-lymphocytic leukemia ntawm Prince of Wales Tsev Kho Mob thiab tau txais kev kho mob induction. Thaum lub Plaub Hlis nws tau mus ua kom tiav kev zam txim nrog kws khomob thiab xov tooj cua. Thiab tsis muaj qhov txawv txav tau pom nyob rau hauv CSF daim ntawv qhia txog kev sib raug zoo.

Txawm li cas los xij, kom txog rau thaum Lub Plaub Hlis 19, 2018, nws cov pob txha pob txha morphology pom 10% ntawm thawj thiab cov menyuam yaus gonorrhoea. Cov kws kho mob hauv Hong Kong xav tias kev siv tshuaj khomob nyuaj ua rau nws ua kom tiav, tsuas yog CAR-T muaj lub sijhawm zoo los ua nws. Tom qab cov kws kho mob pom zoo thiab muab piv rau qhov ua tau zoo thiab kev siv zog, Shawn tuaj rau Lu Daopei Tsev Kho Mob hauv Suav teb los koom nrog CAR-T kev sim tshuaj rau lub Plaub Hlis 23, 2018.

Kev kuaj mob pob txha hauv pob txha tau pom tias nws tsis nyob hauv kev tso cai ua tiav thiab CD19, CD20 yog qhov zoo. Tom qab kev sib tham ntau yam kev qhuab qhia, peb cov kws kho mob haematologist qhia tias nws koom nrog CD19 + CD20 CAR-T kev soj ntsuam kuaj ua ntej pob txha pob txha. Nyob rau hauv peb 300 CAR-T rooj plaub, tag nrho cov nqi them rov qab yog nyob ib ncig ntawm 90%.

Thaum Lub Plaub Hlis 25, Shawn's T-cells tau sau thiab xa mus rau GMP CAR-T lub chaw kuaj mob caj ces. Tom qab tau hloov kho caj ces, T-hlwb tau hloov mus rau "chimeric antigen receptor (CAR) T-cells". CARs yog cov proteins uas pab cov T-hlwb paub txog ib qho antigen hauv cov qog hlwb. Tom qab CAR T hlwb tau loj hlob mus rau qhov txaus rau kev kho mob, CAR T hlwb tau nkag mus rau hauv lawv kom tshem tawm cov qog hlwb.

Shawn tau txais 1 chav kawm ntawm chemotherapy rau lub Tsib Hlis 6, uas yog 5 hnub ua ntej CAR-T cell infusion. Nyob rau lub Tsib Hlis. Thaum Lub Tsib Hlis 11, cov tshuaj txhaj ntawm CD19 CAR-T hlwb tau muab los ua kev kho mob ntawm tes. Tom qab 4 lub lis piam ntawm kev txhawb nqa kev saib xyuas thiab kev tswj xyuas cov kev mob tshwm sim, tsis muaj qhov txawv txav tau pom nyob rau hauv CSF correlation report, flow cytometry, pob txha hlwb morphology, DNA test thiab CAR-T daim ntawv qhia qhia tias nws tau txais kev tso cai tiav.

Ua tiav kev zam txim yog txoj hauv kev zoo tshaj plaws rau nws rov qab mus rau Hong Kong rau cov kauj ruam tom ntej - kev hloov ntshav thiab pob txha pob txha.