Lu Daopei Tsev Kho Mob Kev Kho Mob Tsawg-Dose CD19 CAR-T Qhia Tau Zoo Tshaj Plaws hauv B-ALL Cov Neeg Mob

Hauv kev tshawb nrhiav hauv tsev kho mob Lu Daopei, cov kws tshawb fawb tau tshaj tawm txog kev nce qib tseem ceeb hauv kev kho mob refractory lossis rov ua dua B mob qog ntshav qog ntshav qog ntshav ntshav (B-ALL) siv cov tshuaj qis CD19-qhia CAR-T cell therapy. Txoj kev tshawb no, uas koom nrog 51 tus neeg mob, tau qhia tias txoj hauv kev tshiab no tsis tsuas yog ua tiav qhov kev tshem tawm siab (CR) nkaus xwb tab sis kuj tseem muaj kev nyab xeeb zoo.

Pab neeg tshawb fawb, coj los ntawm Dr. C. Tong los ntawm Department of Hematology thiab Dr. AH Chang los ntawm Clinical Translational Research Center ntawm Tongji University School of Medicine, tau tshawb xyuas qhov cuam tshuam ntawm kev tswj hwm cov koob tshuaj qis ntawm CAR-T hlwb - kwv yees li 1. × 10^5 / kg - piv rau cov pa ntau dua. Txoj hauv kev no txhawm rau txhawm rau sib npaug ntawm kev kho mob nrog kev txo qis ntawm cov kev mob tshwm sim hnyav, tshwj xeeb tshaj yog cytokine release syndrome (CRS).

Cov txiaj ntsig ntawm kev tshawb fawb tau tsim nyog. Ntawm 42 refractory / relapsed B-ALL cov neeg mob, 36 ua tiav CR lossis CR nrog kev suav tsis tiav (CRi), thaum tag nrho cuaj tus neeg mob uas muaj kab mob tsawg (MRD) mus txog MRD tsis zoo. Tsis tas li ntawd, cov neeg mob feem ntau tau ntsib tsuas yog mob me mus rau nruab nrab CRS, nrog rau cov mob hnyav tau tswj hwm tau zoo los ntawm cov tswv yim cuam tshuam thaum ntxov.

Dr. Tong tau hais txog qhov tseem ceeb ntawm txoj kev tshawb fawb no, hais tias, "Cov txiaj ntsig tau qhia tias CD19 CAR-T cell therapy low-dose, tom qab ntawd los ntawm allogeneic hematopoietic qia cell transplantation (allo-HCT), muab kev kho mob zoo rau cov neeg mob uas muaj txwv lwm txoj kev kho no tsis yog tsuas yog muaj cov lus teb siab xwb tab sis kuj tseem txo qis qhov kev pheej hmoo ntawm kev cuam tshuam loj heev. "

Qhov kev vam meej ntawm txoj kev tshawb no qhia txog lub peev xwm ntawm kev kho mob CAR-T cell kho hauv kev kho mob hematological malignancies. Lu Daopei Tsev Kho Mob, muaj npe nrov rau nws txoj haujlwm pioneering hauv cellular immunotherapy, txuas ntxiv ua tus thawj coj hauv kev muab kev kho mob rau cov neeg mob uas muaj teeb meem hematologic.

Raws li txoj kev tshawb fawb tau ua tiav, pab pawg tshawb fawb tau pom zoo txog kev kho kom zoo dua cov tshuaj thiab cov txheej txheem txhawm rau txhim kho cov txiaj ntsig ntawm tus neeg mob. Cov kev tshawb pom los ntawm txoj kev tshawb no tau luam tawm nyob rau hauv phau ntawv journalLeukemiathiab muab kev cia siab rau B-ALL cov neeg mob thoob ntiaj teb.