Lub tswv yim CAR-T Cell Therapies Hloov Kho B Cell Malignancies

Hauv kev tshuaj xyuas tsis ntev los no tau luam tawm hauv Phau Ntawv Xov Xwm ntawm National Cancer Center, cov kws tshaj lij los ntawm Tsev Kho Mob Lu Daopei, coj los ntawm Dr. Peihua Lu, nrog rau cov neeg koom tes los ntawm University of Texas MD Anderson Cancer Center, qhia txog qhov kev nce qib tshiab hauv CAR-T. cell kho rau kev kho mob ntawm B-cell malignancies. Qhov kev tshuaj xyuas no tau tham txog ntau txoj hauv kev tshiab, suav nrog kev hloov pauv ntawm CAR-T cell tsim thiab kev koom ua ke ntawm kev kho cov xov tooj ntawm tes, txhawm rau txhim kho kev ua tau zoo thiab kev nyab xeeb ntawm kev kho mob rau cov kab mob xws li non-Hodgkin's lymphoma (NHL) thiab mob lymphoblastic leukemia (TAG NRHO). ).

B-cell malignancies ua rau muaj teeb meem loj vim lawv nyiam rov qab los thiab txhim kho kev tiv thaiv rau cov kev kho mob. Kev taw qhia ntawm chimeric antigen receptor (CAR) T hlwb tau hloov kho thaj chaw kho mob, muab kev cia siab tshiab rau cov neeg mob ntsib cov mob qog noj ntshav no. Txoj kev tshawb no qhia txog yuav ua li cas CAR T hlwb tuaj yeem tsim kho nrog ntau tiam neeg ntawm kev tsim, suav nrog cov yam ntxwv siab heev xws li bispecific receptors thiab costimulatory domains, kom muaj txiaj ntsig zoo rau cov qog hlwb thiab txo qhov yuav rov qab los.

Lu Daopei Tsev Kho Mob tau ua tus thawj coj ntawm CAR-T cell tshawb fawb thiab daim ntawv thov kev kho mob, ua kom pom qhov ua tau zoo tshaj plaws hauv kev txhawb nqa kev zam mus ntev. Lub tsev kho mob txoj kev koom tes hauv kev ua haujlwm pioneer no qhia txog nws txoj kev mob siab rau kev kho mob qog noj ntshav thiab muab kev saib xyuas zoo tshaj plaws. Kev tshuaj xyuas kuj tseem tshawb txog qhov muaj peev xwm ntawm kev sib txuas CAR-T kev kho mob nrog rau lwm yam kev kho mob, xws li kev tiv thaiv kab mob thiab kev kho mob, kom kov yeej cov txheej txheem tiv thaiv thiab txhim kho cov txiaj ntsig ntawm tus neeg mob.

Cov ntawv tshaj tawm no yog ib qho pov thawj rau kev sib koom tes ntawm cov kws tshawb fawb thoob ntiaj teb thiab cov kws kho mob hauv kev thawb cov ciam teb ntawm kev kho mob qog noj ntshav. Cov kev tshawb pom muaj qhov pom rau yav tom ntej ntawm precision oncology, qhov twg kev kho tus kheej thiab kev kho tshiab tuaj yeem hloov pauv lub neej ntawm cov neeg mob tawm tsam B cell malignancies. Lu Daopei Tsev Kho Mob qhov kev koom tes rau daim teb no yog lub teeb ci ntawm kev cia siab, tsav kev txhim kho kev nyab xeeb thiab zoo dua kev kho mob qog noj ntshav.