Kev Tshawb Fawb Txog Kev Tshawb Fawb Qhia Txog Kev Nyab Xeeb thiab Kev Ua Haujlwm ntawm CAR-T Kev Kho Mob hauv Kev Kho Mob B-Cell Malignancies
Ib txoj kev tshawb fawb tsis ntev los no coj los ntawm Dr. Zhi-tao Ying los ntawm Peking University Cancer Tsev Kho Mob tau pom cov txiaj ntsig tau zoo hauv kev kho mob rov qab thiab refractory B-cell hematologic malignancies siv cov tshiab chimeric antigen receptor T (CAR-T) cell therapy, IM19. Luam tawm nyob rau hauv lubSuav Journal of New Drugs, kev tshawb fawb qhia txog qhov tseem ceeb ntawm kev kho mob muaj peev xwm ntawm IM19 nyob rau hauv cov neeg mob uas tau qaug zog kev kho mob.
Txoj kev tshawb no koom nrog 12 tus neeg mob, sib faib sib npaug ntawm cov neeg mob los ntawm B-cell non-Hodgkin lymphoma (NHL) thiab mob B-cell lymphoblastic leukemia (B-ALL). Cov neeg mob tau txais kev kho mob sib txawv ntawm cov tshuaj IM19 CAR-T hlwb, uas tau muab tso rau tom qab kev kho mob nrog fludarabine thiab cyclophosphamide. Cov ntsiab lus tseem ceeb ntawm txoj kev tshawb no suav nrog kev ntsuam xyuas tag nrho cov lus teb, CAR-T cell persistence, cytokine tso tawm, thiab saib xyuas cov xwm txheej tsis zoo.
(Daim duab qhia txog kev rov zoo ntawm NHL thiab B-Txhua tus neeg mob)
Qhov zoo tshaj plaws, 11 ntawm 12 tus neeg mob tau ua tiav kev tshem tawm, nrog kuaj pom IM19 kev loj hlob hauv lawv cov hlab ntsha. Txoj kev kho no ua rau muaj kev nce hauv cytokines xws li interleukin-6 thiab interleukin-10, qhia txog lub cev tiv thaiv kab mob. Qhov tseem ceeb, tsis muaj leej twg ntawm cov neeg mob tau ntsib kev mob hnyav cytokine tso tawm los yog CAR-T cell-related encephalopathy, underscoring the therapy's favorable safety profile.
Kev tshawb fawb tau ua los ntawm pab pawg sib koom tes los ntawm Peking University Cancer Hospital, Hebei Yanda Lu Daopei Tsev Kho Mob, thiab Beijing Immunochina Pharmaceuticals. Dr. Ying, tus thawj kws sau ntawv, tshwj xeeb hauv kev kuaj mob thiab kho cov qog ntshav qog ntshav, thaum Dr. Jun Zhu, tus sau sau, yog ib tus kws tshaj lij nyob hauv tib qhov chaw. Txoj kev tshawb no tau txais kev txhawb nqa los ntawm ntau qhov nyiaj pab muaj npe, suav nrog National Natural Science Foundation ntawm Tuam Tshoj thiab Beijing Natural Science Foundation.
Qhov kev tshawb fawb pom zoo no muab cov pov thawj tseem ceeb tias IM19 CAR-T txoj kev kho tsis yog tsuas yog siv tau tab sis kuj tseem muaj kev nyab xeeb rau cov neeg mob uas nyuaj B-cell malignancies. Nws ua rau txoj hauv kev rau kev tshawb fawb yav tom ntej thiab muaj peev xwm siv tshuaj kho mob, muab kev cia siab tshiab rau cov neeg mob uas muaj kev xaiv kho mob tsawg.