Diffuse loj B-cell lymphoma (DLBCL), NOS, GCB subtype, thawj hauv nruab nrab paj hlwb lymphoma-01

Thaum lub Kaum Ob Hlis 2019, Mr. Wang, tus kws qhia ntawv los ntawm Northeast Tuam Tshoj, pib mob taub hau. Thaum Lub Kaum Ob Hlis 19th, 2019, kev tshuaj ntsuam xyuas tau qhia txog cov hauv qab no: PET-CT pom cov duab ntxoov ntxoo ntom ntom nrog cov metabolism hauv FDG ntau ntxiv nyob rau sab laug pem hauv ntej lobe thiab corpus callosum hauv caug cheeb tsam (kwv yees li 3.4 * 1.9 cm, SUVmax = 34.4). Biopsy thiab immunohistochemistry paub tseeb tias nthuav dav B-cell lymphoma (DLBCL, NOS, GCB subtype), nrog rau immunophenotype qhia Ki67(50%+), CD19(+), CD20(+), PAX5(+), CD79(+), MUM1(+), BCL(+), CD10(-/+), CD2(me+). Cerebrospinal kua tsom xam pom 6% cov hlwb tsis paub qab hau nrog kev hloov pauv ntawm morphological. Kev kuaj mob yog thawj lub hauv paus paj hlwb lymphoma (DLBCL, GCB subtype).

Tom qab tshawb nrhiav kev kho mob hauv online, Mr. Wang tau kawm txog Lu Dao Pei Tsev Kho Mob lub peev xwm tiv thaiv kab mob thiab tau nrhiav lawv cov kws tshaj lij tam sim ntawd. Tom qab kev tshuaj xyuas lub cev kom zoo thiab kev tshuaj xyuas zoo los ntawm pab pawg kws tshaj lij hauv tsev kho mob, nws tau txiav txim siab tias Mr. Wang yuav koom nrog kev sim tshuaj kho mob CART, tshwj xeeb yog siv CD19 CART hlwb. Nws tau txais autologous CD19 CAR-T cell infusion rau lub Plaub Hlis 24, 2023. Txog rau Lub Xya Hli 30, 2023, nws tau raug soj ntsuam kom ua tiav kev zam txim (CR) thiab txij li ntawd tau rov qab mus rau lub neej qub.