Diffuse loj B-cell lymphoma (DLBCL)-04

Mr. Li, 64 xyoo (tsim npe), tau kuaj pom tias muaj mob loj B-cell lymphoma (DLBCL) plaub xyoos dhau los, uas tau nce mus rau theem kawg kev koom tes ntawm tus po, tav, ntsws, thiab pleura, cais raws li theem IV. . Tom qab thawj kab immunochemotherapy, nws tus mob tseem nyob rau hauv kev zam txim rau ntau tshaj peb xyoos. Txawm li cas los xij, nyob rau lub Peb Hlis xyoo tas los, nws tus kab mob rov zoo dua, cuam tshuam nrog ntau cov qog ntshav retroperitoneal. Txawm hais tias qhov thib ob-kab khaws cia cov tshuaj khomob, nws tsuas yog ua tiav ib feem ntawm kev tshem tawm thiab ua kom tsis zoo sai sai, xav tau kev kho kom zoo dua los tswj kev nce qib ntxiv.

Tau ntsib nrog qhov kev nyuaj siab no, pab pawg kws tshaj lij ntawm Lu Daopei Tsev Kho Mob tau tshuaj xyuas Mr. Li cov ntaub ntawv thiab tau teeb tsa pab pawg neeg sib tham (MDT) lub rooj sib tham kom pom zoo CAR-T cell therapy. CAR-T cell therapy, raws li daim ntawv tshiab tshaj plaws ntawm cov qog immunotherapy, muaj cov txiaj ntsig tseem ceeb xws li lub hom phiaj muaj zog thiab ua kom muaj txiaj ntsig zoo rau cov neeg mob uas rov qab los thiab cov qog ntshav qab zib refractory.

Thaum Lub Ib Hlis 2023, Mr. Li tau txais kev kho mob CAR-T cell ntawm lub Lymphoma Department. Ua ntej kev kho mob, nws tau mus kuaj ntshav ntawm txoj cai inguinal lymph nodes, uas tau lees paub CD19 thiab CD20 zoo, muab lub hom phiaj meej rau CAR-T cell therapy. Raws li kev qhia ntawm Xib Fwb Li, pab neeg kho mob tau tsim ib txoj kev kho tus kheej.

Thaum Lub Xya Hli 25, 2023, Mr. Li tau ua tiav cov txheej txheem infusion ntawm CD19/20 CAR-T hlwb, uas tau ua tiav raws li kev saib xyuas zoo los ntawm pab pawg kws kho mob. Txawm hais tias muaj cytokine tso tawm syndrome, cytopenia, thiab kev pheej hmoo kis mob tom qab infusion, kev saib xyuas nruj me ntsis tau tswj xyuas qhov tsis zoo thaum kho.

Rau lub hlis tom qab siv CAR-T cell therapy, Mr. Li tsis pom muaj qhov tshwm sim tseem ceeb hauv nws lub cev, ua tiav cov lus teb metabolic (CMR), uas ua rau muaj kev cia siab tshiab rau nws txoj kev noj qab haus huv. Pab neeg kho mob ntxiv ntxiv cov kab mob retroperitoneal residual nrog radiotherapy los xyuas kom meej cov kab mob ua kom tiav thiab ruaj khov mus ntev.

Los ntawm CAR-T cell immunotherapy, Mr. Li tsis tsuas yog ua tiav kev txhim kho tseem ceeb hauv nws tus mob, tab sis kuj tau txais kev ntseeg siab thiab tseem ceeb hauv lub neej. Nws cov ntaub ntawv muab kev cia siab tshiab thiab kev taw qhia rau cov neeg mob qog ntshav qog ntshav thiab ua kom pom qhov muaj peev xwm thiab ua tau zoo ntawm CAR-T cell therapy hauv kev kho mob qog noj ntshav refractory lymphoma.

CAR-T cell therapy, raws li kev kho mob qog noj ntshav tshiab, tab tom hloov lub neej txoj hauv kev ntawm cov neeg mob nrog refractory lymphoma. Raws li kev saib xyuas zoo ntawm pab pawg kws tshaj lij ntawm Lub Tsev Haujlwm Lymphoma, cov neeg mob ntau dua li Mr. Li tuaj yeem xav tias yuav muaj kev txhim kho tseem ceeb hauv kev ciaj sia thiab lub neej zoo. Saib tom ntej, kev nce qib ntxiv thiab kev siv ntawm CAR-T cell therapy cog lus rau kev cia siab ntau dua thiab muaj peev xwm kho mob qog noj ntshav.