Mob Lymphoblastic Leukemia (T-ALL)-10
Ib tug me nyuam tub muaj 13 xyoos npe hu ua Yangyang los ntawm Panzhihua, Sichuan Province, tau txais CAR-T tom qab hla kev cog qoob loo.
Yangyang tau nthuav tawm thawj zaug nrog "pob txha tawg thoob plaws hauv lub cev nrog rau kev qaug zog" thaum lub Plaub Hlis 12, 2021. Nws tau kuaj pom tias muaj tus mob lymphoblastic leukemia (T-cell subtype) nrog intracranial hemorrhage thiab mob ntsws tau lees paub los ntawm cov pob txha pob txha MICM kuaj ntawm lub tsev kho mob loj hauv Chongqing. Nws tau txais 3 lub voj voog ntawm kev kho mob ntawm lwm lub tsev kho mob, tab sis pob txha pob txha tsis teb. Txog rau thaum lub Rau Hli, nws tsim kev qaug zog ntawm ob sab ceg qis thiab taug kev tsis tau.
Thaum Lub Xya Hli 1, 2021, Yangyang tau txais mus rau peb Lub Tsev Haujlwm Saib Xyuas Kev Kho Mob Hematology Ward 2. Nws tau cuv npe hauv CD7 CAR-T kev sim tshuaj rau lub Xya Hli 8 thiab tau txais autologous CD7 CAR-T cell infusion rau Lub Xya Hli 26 rau kev tiv thaiv kab mob. Kaum rau hnub tom qab infusion, pob txha pob txha morphology pom kev tso tawm, thiab ntws cytometry qhia 0.07% tsis txaus ntseeg malignant tsis paub tab T lymphoblasts. Tom qab kev kho lub cev, nws rov muaj peev xwm taug kev ntawm nws tus kheej. Los ntawm hnub 31 tom qab kev txhaj tshuaj, nws cov pob txha pob txha ua tiav tiav.
Tam sim no, Yangyang tau raug xa mus rau Ward 6 ntawm Lub Tsev Haujlwm Saib Xyuas Kev Kho Mob Pob Txha rau kev kho mob ntxiv. Dr. Hai los ntawm Ward 6 tau hais tias Yangyang tau koom tes ua haujlwm zoo thiab muaj kev cia siab thoob plaws nws txoj kev kho mob. Nws underwent allogeneic hematopoietic qia cell transplantation (los ntawm nws txiv) thaum lub Cuaj Hlis 28. Cov xwm txheej tsim los ntawm Hematology Department cov npoj yaig rau nws txoj kev hloov pauv tau zoo heev.
Cov neeg mob no, ua ntej tso npe rau hauv CD7 CAR-T kev sim tshuaj ntsuam xyuas, nthuav tawm ntau yam tsos mob xws li tom qab hloov pauv rov qab, T / myeloid dual qhia, refractory / resistant mob T-cell leukemia, central paj hlwb leukemia, intracranial hemorrhage, thiab mob ntsws. Tom qab kev ntsuam xyuas thiab kev kho mob nrog CD7 CAR-T txoj kev kho, txhua yam ua tiav tiav, ua tiav cov txiaj ntsig xav tau.
Lub Tsev Kho Mob Ludaopei tau nquag tshawb nrhiav hauv kev kho CAR-T thiab tau txais kev paub nplua nuj hauv kev tswj hwm CRS. Rau feem ntau cov neeg koom, qhov tshwm sim loj tshaj plaws yog kub taub hau. "Kuv tuaj yeem ua tiav kev zam txim, yog li qhov kub taub hau tsis muaj dab tsi! Kuv xav kom ntau tus neeg paub tias Ludaopei tuaj yeem ua CAR-T!" hais tias Yangyang los ntawm Fujian thaum tso tawm.
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