Mob Lymphoblastic Leukemia (T-ALL)-07

Ib tug ntxhais Miao tau ua tiav kev zam txim tom qab CAR-T kho tom qab hloov pauv rov qab.

Amei, tus tub kawm tiav qib siab los ntawm Hunan ntawm haiv neeg Miao, tau luam tawm ob daim ntawv SCI. Lub Plaub Hlis 2, 2020, nws tau mus pw hauv tsev kho mob hauv xeev vim yog kub taub hau. Kev kuaj mob pob txha kuaj pom nws muaj mob qog ntshav qog ntshav qog ntshav (T-ALL). Tom qab ntau chav kawm ntawm chemotherapy ntawm lub tsev kho mob sab nraud, nws cov pob txha pob txha tseem nyob hauv kev zam. Thaum Lub Kaum Ib Hlis 2, 2020, nws tau hloov pauv cov kab mob hematopoietic stem cell ntawm allogeneic ntawm peb lub tsev kho mob (kwv tij-rau-viv ncaus, HLA 7/10 match). Tom qab hloov pauv, cov hlwb tau ua tiav tiav, thiab kev soj ntsuam xyuas cov pob txha pob txha tau pom tias muaj kev tshem tawm.

Thaum Lub Rau Hli 16, 2021 (7 lub hlis tom qab hloov pauv), kev kuaj xyuas niaj hnub tau qhia txog kev rov qab los ntawm nws cov kab mob leukemia. Cov kws khomob tom qab tsis tuaj yeem tswj tau tus kabmob, thiab nws tsim muaj mob ntsws thiab mob herpes tus kab mob, nrog rau qhov mob ntawm qhov ncauj ua rau nqos nyuaj. Nws tau txais mus rau hauv pawg ntseeg thib ob ntawm lub tuam tsev kho mob hematology thiab tau tso npe rau hauv CD7 CAR-T kev sim tshuaj.

Tus thawj coj Yang Junfang pab neeg kho mob tau muab kev kho mob tiv thaiv kab mob, kho qhov mob, thiab kev siv cov ntshav thiab platelet ntau ntxiv. Vim lub nra hnyav heev (80% blasts nyob rau hauv cov pob txha pob txha thiab 97% blasts nyob rau hauv peripheral cov ntshav), nws tsis muaj peev xwm mus sau nws cov hlwb. Peripheral ntshav lymphocytes los ntawm tus pub (nws tus kwv) tau sau thiab xa mus rau lub tuam txhab biotech rau CAR-T cell kab lis kev cai.

Thaum Lub Yim Hli 10, 2021, CD7 CAR-T hlwb tau muab cov neeg pub dawb rov qab. Tom qab reinfusion, CAR-T hlwb tau nthuav dav mus rau 54.64% hauv cov ntshav peripheral, tsuas yog kub taub hau thiab tsis muaj qhov tseem ceeb cytokine release syndrome (CRS) lossis kab mob graft-tiv thaiv tus tswv tsev (GVHD). Kev kuaj mob pob txha rau hnub 16 tom qab rov ua dua tshiab tau pom tias ua tiav kev tshem tawm, nrog 54.13% CAR-T hlwb hauv cov pob txha. Nyob rau hnub 36, cov pob txha pob txha txuas ntxiv qhia tias muaj kev zam txim. Tam sim no, nws lub siab lub ntsws, pw tsaug zog, thiab qab los noj mov zoo, thiab nws rov zoo.