Mob Lymphoblastic Leukemia (T-ALL)-06

Tus neeg mob uas muaj hnub nyoog 2 xyoos nrog T-ALL tau txais kev tso cai tom qab CAR-T kho tom qab ntau tshaj kaum qhov kev kho mob hnyav.

Ob xyoos Xiaohong los ntawm Zhejiang tau kuaj pom tias muaj kab mob leukemia lub caij ntuj sov dhau los. Tom qab ntau tshaj li ib xyoos ntawm kev kho mob, ntws cytometry kuaj pom qhov rov qab los, ua rau tsev neeg mus nrhiav CAR-T immunotherapy ntawm Lu Daopei Tsev Kho Mob.

Thaum Lub Yim Hli 9, 2020, Xiaohong tau mus pw hauv tsev kho mob menyuam yaus hauv zos vim "ua npaws peb hnub." Cov pob txha pob txha MICM kuaj tau kuaj pom tus mob lymphoblastic leukemia (T-ALL). Tom qab ib chav kawm ntawm chemotherapy, cov pob txha pob txha morphology tau pom tias ua tiav kev tshem tawm, thiab cov cytometry ntws tsis pom cov hlwb tsis paub tab. Tom ntej no intensive chemotherapy tshaj 11 cov kev kawm tswj kom tiav kev tshem tawm cov pob txha.

Thaum lub Cuaj Hlis 3, 2021, kev soj ntsuam ntawm cov pob txha pob txha puncture pom tias ua tiav kev tso tawm hauv morphology, tab sis ntws cytometry qhia 1.85% malignant tsis paub tab. Nrhiav kev kho mob ntxiv, Xiaohong tau mus rau Yanda Lu Daopei Tsev Kho Mob thaum lub Cuaj Hlis 24. Thaum nkag mus, cov pob txha pob txha morphology tseem nyob hauv kev ua kom tiav, tab sis kev tiv thaiv kab mob qhia tau tias 0.10% malignant T lymphocytes tsis paub qab hau.

Xav txog Xiaohong lub hnub nyoog hluas thiab kev pheej hmoo ntawm tus kab mob txawm tias dhau kaum qhov kev kho mob hnyav, pab pawg kho mob hauv pawg thib ob ntawm lub tuam tsev hematology tau txiav txim siab tias Xiaohong tuaj yeem tso npe rau hauv CD7 CAR-T kev sim tshuaj.

Thaum lub Cuaj Hlis 30, 2021, cov qe ntshav peripheral tau sau rau CAR-T cell kab lis kev cai. Thaum Lub Kaum Hli 10, Xiaohong tau txais FC cov kws khomob khomob. Thaum Lub Kaum Hli 13, cov pob txha pob txha tau pom tsawg dua 5% blasts hauv morphology, thiab ntws cytometry qhia 0.37% malignant tsis paub tab T hlwb. Thaum Lub Kaum Hli 15, CD7 CAR-T hlwb tau rov ua dua.

Thaum Lub Ib Hlis 3 (20 hnub tom qab rov ua dua tshiab), cov pob txha pob txha pob txha pom tau tias ua tiav kev tso tawm hauv morphology, tsis muaj cov hlwb tsis paub tab pom los ntawm kev ntws cytometry. Xiaohong tus mob tau nyob ruaj khov, thiab nws tau raug xa mus rau lub chaw hloov pauv los npaj rau kev hloov pauv ntawm cov qia hlwb allogeneic hematopoietic.

Xiaohong muaj hnub nyoog tsawg dua ib xyoos thaum nws poob mob thiab tau nyiaj dhau ib xyoos ntawm kev kho tshuaj. Txoj kev vam meej rau kev hloov pauv tom qab CD7 CAR-T txoj kev kho tau muab riam phom muaj zog los tiv thaiv tus kab mob.