Hōʻike ʻia ʻo TIL Therapy: E ʻimi ana i ka ʻāina o ka maʻi maʻi maʻi maʻi
He aha ka Tils Therapy?
ʻO ka lāʻau lapaʻau ʻo TILs ka unuhi ʻana i nā lymphocytes infiltrating tumor (TILs), ʻo ia nā mea kūlohelohe maoli anti-tumor immune cell i loko o ke kino o ka mea maʻi, mai kahi maʻi maʻi a hoʻoulu iā lākou i nā helu nui i loko o kahi lab. Hoʻokomo hou ʻia kēia mau TIL i hoʻāla ʻia i loko o ke kino o ka mea maʻi no ka hoʻoikaika ʻana i ka hiki o ka ʻōnaehana pale ke hoʻopaʻa a pepehi i nā maʻi maʻi. Hana nā TIL ma ka ʻike ʻana i nā māka kikoʻī ma nā pūnaewele maʻi maʻi a me ka hoʻokuʻu ʻana i kahi pane kūlohelohe e kūʻē iā lākou, e alakaʻi ana i ka luku ʻana i ka maʻi maʻi.
He aha ke kaʻina hana o Tils Therapy?
Nā hopena lapaʻau o Tils Therapy
Ma muli o kā mākou hopena lapaʻau lapaʻau, hiki i ka pono holoʻokoʻa o TILs monotherapy i ke kiʻekiʻe a hiki i 40%, ʻo ia ke ʻano hana lapaʻau ʻoi loa ka maikaʻi loa ma waho o ke kaʻina i loaʻa i kēia manawa. E hui pū ʻia kekahi a i ʻole kekahi mau lāʻau lapaʻau me Tils therapy, kahi e hoʻonui ai i ka nui o ka hopena i ʻoi aku ma mua o 80%. ʻO ka lāʻau hui pū ka manaʻo e hōʻemi i ka ukana maʻi maʻi i ka wā pōkole, a hāʻawi nā tils i kahi manawa no ka mea maʻi e ola ai i ka holo lōʻihi.
Pono o Tils Therapy
Kūlana kiʻekiʻe:ʻike ʻia e nā ʻano TCR he nui
ʻO ka tropism ikaika:hōʻike kiʻekiʻe o nā mea hoʻokipa chemokine, tropism tumo ikaika, a me ka hana wikiwiki
Ka pepehi ʻana i nā ʻōpū:Hoʻohana ʻia nā TIL a hoʻonui ʻia i 109-1011, a hoʻomaʻemaʻe ʻia nā koena maʻi maʻi ma hope o ke kaʻe ʻana.
Ka hopena mau:He kiʻekiʻe ka nui o nā pūnaewele T hoʻomanaʻo, a hiki ke ola i loko o ke kino no ka manawa lōʻihi a nānā mau ʻia.
Palekana kiʻekiʻe:ka unuhi ʻana, ka hoʻonui ʻana, ʻaʻohe pane hōʻole, a me ka SAE o nā pūnaewele TIL mai nā maʻi ponoʻī
Nā hōʻailona no ka Tils Therapy
Ua hōʻoia maikaʻi ʻo Tils therapy maNSCLC (non-small cell lung cancer),Melanoma, Ka maʻi maʻi umauma,Ka maʻi maʻi ʻāʻī,a me ka maʻi maʻi ovarian.
ʻO wai nā ʻiʻo hiki ke hoʻohana ʻia e unuhi i nā TIL?
Ma waho aʻe o ka ʻoki ʻoki ʻana o ka ʻōpū mua, hiki ke hoʻāʻo ʻia no ka unuhi ʻana. ʻO ka pae o ka hopena penei: ʻeha mua ≥ ʻeha metastatic ≥ lymph nodes ≥ ascites.
Hiki i nā poʻe maʻi āpau ke hoʻoulu maikaʻi i nā TIL?
Loaʻa i kā mākou kaʻina hana kanu TIL i hoʻomohala kūʻokoʻa i ka helu kūleʻa o ≥85%. Me kahi laʻana kiko maʻamau o ≥1cm3, hiki ke mahi ʻia nā piliona TIL, a hōʻike nā cell i ka hana cytotoxic ikaika."
Nā hopena ʻaoʻao o ka lāʻau lapaʻau TIL?
ʻO 1.TIL nā pūnaewele pono'ī o ka mea maʻi, no lailaʻaʻohe pilikia o ka hōʻoleʻana, e hōʻoia ana i ka palekana kiʻekiʻe.
2. Nā hopena ʻino: He mea maʻamau ke kuni (ma muli o ka hoʻokuʻu ʻia ʻana o nā cytokines i ka wā o ka TILs cell-mediated tumor clearance, hoʻoulu i ke kuni liʻiliʻi, ʻaʻole pono e mālama pono ʻia a hoʻoponopono iā ia iho).
3. ʻO nā hopena ʻino ʻē aʻe i hōʻike ʻia i loko o nā haʻawina e pili ana i ka thrombocytopenia, febrile neutropenia, hypertension, a me nā mea ʻē aʻe, ka hapa nui o nā TIL i hui pū ʻia me nā lāʻau lapaʻau e like me ka chemotherapy pre-treatment (cyclophosphamide + fluorouracil), IL-2 kiʻekiʻe, PD-1 nā antibodies monoclonal, etc.
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