Systemic Lupus Erythematosus (SLE)-03
I ʻAukake 2016, ua loaʻa ʻo Ms. A he 20 makahiki i nā kiko ʻulaʻula liʻiliʻi ma kona kino a me ke kuni pinepine, a ua loaʻa iā ia ka helu platelet haʻahaʻa, ʻehiku mahina ma hope o ka hānau ʻana. Ma hope o nā hoʻokolohua he nui i nā halemai kūloko, ua ʻike ʻia ʻo ia me ka systemic lupus erythematosus (SLE) ma kahi haukapila kūloko. I ʻOkakopa o ia makahiki hoʻokahi, ua hoʻomaka ʻo ia e mālama i ka lāʻau lapaʻau ma kona haukapila kūloko.
"No nā makahiki ʻehiku i hala iho nei, pono wau e kipa i ka haukapila i kēlā me kēia mahina no ka hoʻomaʻamaʻa ʻana, ka hoʻāʻo ʻana i ke koko, ka hoʻāʻo ʻana i ka mimi, a me nā lāʻau lapaʻau a me nā injections mau, akā ua hoʻomau ʻia ke ʻano, he mea ʻeha loa," wahi a Ms. I ka hoʻoikaika ʻana e mālama i kona maʻi, ua lawe kāna kāne iā ia i kekahi mau haukapila, akā ʻaʻole i hōʻoluʻolu ʻia ke kumukūʻai kiʻekiʻe i kona kūlana. I ka hopena, ua hoʻomohala ʻo ia i ka lupus nephritis a me ka encephalopathy, a i Kepakemapa 2022, ua hana ʻo ia i ka ʻoki lolo. I ka lohe ʻana he hiki i ka lāʻau lapaʻau CAR-T ke mālama i ka SLE, ua ʻimi ʻo Ms. A i ke kōkua mai ko mākou haukapila, kahi i kālele koke ai ka hui loea i kona kūlana.
Ua wehewehe ke kauka, "I ka wā i hoʻokomo mua ʻia ai kēia maʻi, ua loaʻa iā ia ka edema maʻamau, proteinuria nui, a me nā antibodies maikaʻi. encephalopathy, pulmonary hypertension, pulmonary fibrosis, a me kāna biopsy renal i hōʻike i ka lupus ikaika. Ke hoʻohālikelike ʻia me nā lāʻau kemika kuʻuna a i ʻole nā antibody monoclonal, hiki i nā pūnaewele CAR-T ke komo i nā pale o ka ʻiʻo, e puʻunaue ākea i loko o nā ʻiʻo, a hoʻokau i kahi hopena cytotoxic, ʻoi aku hoʻi i nā cell B a i ʻole nā pūnaewele plasma i nā ʻāpana kiko i hiki ʻole ke loaʻa e nā antibodies monoclonal. Me ka 'ole o ka 'ano o ka ma'i,' e emi malie ana na autoantibodies o ka mea ma'i, e hoopiha ana i ka mea ma'amau, a e ho'omaha malie a nalo paha na ma'i."
Ua ʻōlelo ʻo Ms. A, "I kēia manawa ua pau nā kiko ʻulaʻula o koʻu kino, ʻaʻohe oʻu makemake hou i nā lāʻau hormone a i ʻole immunosuppressants. Ua hoʻāʻo pinepine au i ke koko a me ka mimi, akā i kēia manawa pono wau i kēlā me kēia mahina ʻeono. ʻO koʻu kūlana holoʻokoʻa. maikaʻi, a he mea maʻamau nā hōʻailona a pau i kēia lā ke kolu o kaʻu kipa ʻana, a ua maikaʻi nā hopena o nā kipa ʻelua i hala.
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