Shawn [Inoa Hope ʻAʻole Hāʻawi ʻia]----Acute B-lymphocytic Leukemia (B-ALL)

ʻO ka hoʻokolohua lapaʻau maikaʻi loa ʻo CAR-T e hoʻopakele i ka maʻi maʻi Hong Kong B-ALL.

ʻO Shawn, he 29 ona makahiki mai Hong Kong. Ma Malaki 2017, loaʻa nā hōʻailona o ke kuni, ka luhi a me ka ʻeleʻele. Ua ʻike ʻia ʻo ia me ka maʻi maʻi B-lymphocytic leukemia ma ka Halemai ʻo Prince of Wales a loaʻa iā ia ka chemotherapy induction. I ʻApelila, ua kala ʻia ʻo ia me ka chemotherapy a me ka radiotherapy. A ʻaʻohe mea ʻino i ʻike ʻia ma ka hōʻike hoʻoponopono CSF.

Eia nō naʻe, a hiki i ka lā 19 ʻApelila 2018, ua hōʻike ʻia ka morphology o kāna iwi iwi i ka 10% o ka maʻi gonorrhea mua a me ka juvenile. Manaʻo nā kauka Hong Kong he paʻakikī ka chemotherapy e hoʻolilo iā ia i ke kala piha, ʻo CAR-T wale nō ka manawa kūpono e hana ai. Ma hope o ka ʻōlelo a nā kauka a me ka hoʻohālikelike ʻana i ka helu kūleʻa a me ka hoʻoikaika ʻana, hele mai ʻo Shawn i ka Halemai Lu Daopei ma Kina e komo i ka hoʻokolohua lapaʻau CAR-T ma 23 ʻApelila 2018.

Ua hōʻike ʻia ka hōʻike biopsy iwi iwi komo ʻaʻole ʻo ia i ke kala piha a maikaʻi ka CD19, CD20. Ma hope o kahi kūkākūkā multidisciplinary, ʻōlelo ko mākou haematologists e komo ʻo ia i ka CD19+CD20 CAR-T hoʻokolohua ma mua o ka hoʻololi ʻana i ka iwi iwi. Ma kā mākou mau hihia CAR-T 300, ʻo ka helu kala ʻana piha ma kahi o 90%.

Ma ka lā 25 ʻApelila, hōʻiliʻili ʻia nā T-cell o Shawn a hoʻouna ʻia i ka hale hana GMP CAR-T no ka ʻenekinia genetic. Ma hope o ka hoʻololi ʻia ʻana, ua hoʻololi ʻia nā T-cell i "chimeric antigen receptor (CAR) T-cells". ʻO nā CAR he mau protein e kōkua ana i nā pūnae T e ʻike i kahi antigen i loko o nā pūnaewele maʻi tumora. Ma hope o ka ulu ʻana o nā pūnaewele CAR T i ka nui kūpono no ka mālama ʻana, ua hoʻokomo ʻia nā pūnaewele CAR T i loko o lākou e hoʻopau i nā pūnaewele tumo.

Ua loaʻa iā Shawn he 1 papa o ka chemotherapy ma ka lā 6 o Mei, ʻo ia ka 5 mau lā ma mua o ka infusion cell CAR-T. Ma Mei. Ma ka lā 11 Mei, ua hāʻawi ʻia ka infusion o nā cell CD19 CAR-T ma ke ʻano he immunotherapy cellular. Ma hope o 4 mau pule o ka mālama kākoʻo a me ka hoʻokele hopena ʻaoʻao, ʻaʻohe mea ʻino i ʻike ʻia i ka hōʻike hoʻoponopono CSF, kahe cytometry, iwi iwi iwi morphology, DNA hōʻike a me CAR-T hōʻike i hōʻike ʻia ua loaʻa iā ia ke kala piha.

ʻO ka loaʻa ʻana o ke kala piha ʻana ʻo ia ke ala maikaʻi loa e hoʻi ai i Hong Kong no ka hana hou aʻe—he hoʻololi ʻana i ke koko a me ka iwi iwi.