ʻO ka maikaʻi lōʻihi o ka CD19 CAR T-Cell Therapy i ka mālama ʻana i ka Leukemia Lymphoblastic Acute Relapsed/Refractory.

Ma kahi holomua nui i ka hana o ka hematology, ua hōʻike ʻia kahi noiʻi hou i ka hopena lōʻihi o ka CD19 chimeric antigen receptor (CAR) T-cell therapy i nā maʻi e loaʻa ana i ka relapsed/refractory acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem. ka hoʻololi ʻana o ke kelepona (allo-HSCT). ʻO ke aʻo ʻana, e hahai ana i nā mea maʻi i kahi manawa lōʻihi, hāʻawi i kahi loiloi piha o nā hopena, e hāʻawi ana i nā ʻike koʻikoʻi i ka paʻa a me ka palekana o kēia lapaʻau hou.

Ua nānā pono ka haʻawina i nā maʻi i loaʻa i ka CD19 CAR T-cell therapy ma hope o ka loaʻa ʻana o ka hoʻi hou ʻana o ALL ma hope o allo-HSCT. Ke hoʻohiki nei nā hopena, e hōʻike ana he hapa nui o nā maʻi i loaʻa i ke kala piha, me nā pane hoʻomau i ʻike ʻia i nā makahiki. ʻAʻole hōʻike wale kēia noiʻi i ka hiki ke hoʻōla ʻia o CAR T-cell therapy akā hōʻailona pū kekahi i kahi milestone i ka mālama ʻana i nā maʻi maʻi hematological, ʻoi aku hoʻi no ka poʻe me nā koho lapaʻau liʻiliʻi.

Eia kekahi, ʻike ka haʻawina i ka ʻike palekana o ka lāʻau lapaʻau, e hōʻike ana i nā hopena ʻaoʻao hiki ke mālama ʻia, i kūlike me nā ʻike mua. Hoʻoikaika kēia i ka ulu ʻana o ka hilinaʻi i ka CAR T-cell therapy ma ke ʻano he lapaʻau kūpono a maikaʻi hoʻi no ka hoʻihoʻi ʻana/refractory ALL, ʻoi aku ma kahi hoʻonohonoho post-transplant.

Ke hoʻomau nei ka ulu ʻana o ke kahua o ka immunotherapy, lilo kēia haʻawina ma ke ʻano he kukui o ka manaʻolana no nā poʻe maʻi a me nā mea mālama ola kino, e hoʻohiki ana i ka wā e hiki mai ana i hiki i nā mea maʻi ke loaʻa i ke kala lōʻihi. ʻAʻole kōkua wale nā ​​ʻike i ka ulu ʻana o nā hōʻike e kākoʻo ana i ka lāʻau lapaʻau T-cell CAR akā hāʻawi pū i ke ala no ka noiʻi hou ʻana e hoʻonui a hoʻonui i kāna hoʻohana ʻana i nā hoʻonohonoho lapaʻau.

Me kēia holomua, ua kokoke ke kaiāulu olakino e hoʻololi i ka ʻāina lapaʻau no nā maʻi maʻi hematological, e hāʻawi ana i ka manaʻolana hou i nā poʻe maʻi e hakakā nei i kēia mau kūlana paʻakikī.