Hoʻololi ʻia nā lāʻau lapaʻau CAR-T hou i ka mālama ʻana i nā maʻi maʻi B

Ma kahi loiloi hou i paʻi ʻia ma ka Journal of the National Cancer Center, nā loea mai ka Halemai ʻo Lu Daopei, alakaʻi ʻia e Kauka Peihua Lu, a me nā hoa hana mai The University of Texas MD Anderson Cancer Center, e hoʻomālamalama i nā holomua hou loa ma CAR-T nā lāʻau lapaʻau no ka mālama ʻana i nā maʻi maʻi B-cell. Kūkākūkā kēia loiloi piha i kekahi mau ala hou, e like me ka hoʻomohala ʻana o ka hoʻolālā cell CAR-T a me ka hoʻohui ʻana o nā mea lapaʻau cell adoptive, e hoʻomaikaʻi i ka pono a me ka palekana o nā lāʻau lapaʻau no nā maʻi e like me ka non-Hodgkin's lymphoma (NHL) a me ka leukemia lymphoblastic acute (ALL). ).

He mau pilikia koʻikoʻi nā maʻi maʻi B-cell ma muli o ko lākou ʻano e hoʻi hou a hoʻomohala i ke kūʻē ʻana i nā lāʻau lapaʻau maʻamau. ʻO ka hoʻokomo ʻana o nā pūnaewele chimeric antigen receptor (CAR) T ua hoʻololi i ka ʻāina lapaʻau, hāʻawi i ka manaʻolana hou i nā poʻe maʻi e kū nei i kēia mau maʻi maʻi ʻino. Hōʻike ka haʻawina i ke ʻano o ka hana ʻana o nā pūnaewele CAR T me nā hanauna he nui o ka hoʻolālā, e hoʻopili ana i nā hiʻohiʻona kiʻekiʻe e like me ka bispecific receptors a me nā kāʻei costimulatory, i ʻoi aku ka maikaʻi o ka huli ʻana i nā cell tumor a hōʻemi i ka hiki ke hoʻi hou.

Aia ka Halemai Lu Daopei ma mua o ka noiʻi cell CAR-T a me ka noi lapaʻau, e hōʻike ana i ka kūleʻa kupaianaha i ka hoʻoulu ʻana i nā kala kala lōʻihi. ʻO ke komo ʻana o ka haukapila i kēia hana paionia e hōʻike ana i kāna kūpaʻa i ka holomua ʻana i ka mālama ʻana i ka maʻi kanesa a me ka hoʻolako ʻana i ka mālama hou. ʻIke pū ka loiloi i ka hiki ke hoʻohui i nā lāʻau lapaʻau CAR-T me nā lāʻau lapaʻau ʻē aʻe, e like me ka immunotherapy a me nā lāʻau lapaʻau i hoʻopaʻa ʻia, e lanakila ai i nā mīkini pale a hoʻomaikaʻi i nā hopena maʻi.

He hōʻike kēia paʻi ʻana i ka hana like ʻana o nā mea noiʻi honua a me nā kauka lapaʻau i ke koi ʻana i nā palena o ka mālama ʻana i ka maʻi kanesa. Hāʻawi nā ʻike i kahi ʻike i ka wā e hiki mai ana o ka oncology precision, kahi e hiki ai i nā lāʻau lapaʻau pilikino a me nā mea hou ke hoʻololi i ke ola o nā maʻi e hakakā nei i nā maʻi maʻi B cell. ʻO nā haʻawina a ka Halemai ʻo Lu Daopei i kēia kahua he kukui o ka manaʻolana, e alakaʻi ana i ka hoʻomohala ʻana i nā lāʻau lapaʻau palekana a ʻoi aku ka maikaʻi.