Hōʻike ʻo Breakthrough Study i ka palekana a me ka maikaʻi o ka Therapy CAR-T i ka mālama ʻana i nā maʻi maʻi B-Cell.
Ua hōʻike ʻia kahi noiʻi hou i alakaʻi ʻia e Kauka Zhi-tao Ying mai ka Halemai maʻi maʻi maʻi o ke Kulanui o Peking i nā hopena hoʻohiki i ka mālama ʻana i nā maʻi maʻi hematologic B-cell me ka hoʻohana ʻana i kahi novel chimeric antigen receptor T (CAR-T) cell therapy, IM19. Paʻi ʻia ma kaKa Nupepa Pake o na Laau Laau Hou, hōʻike ka noiʻi i ka mana therapeutic koʻikoʻi o IM19 i nā maʻi i hoʻopau i nā koho lapaʻau maʻamau.
Ua pili ka haʻawina i nā maʻi 12, i māhele like ʻia ma waena o ka poʻe i loaʻa i ka lymphoma non-Hodgkin B-cell (NHL) a me ka maʻi maʻi B-cell lymphoblastic leukemia (B-ALL). Ua mālama ʻia ka poʻe maʻi me nā ʻano like ʻole o nā cell IM19 CAR-T, i hoʻokomo ʻia ma hope o kahi regimen conditioning e pili ana i ka fludarabine a me ka cyclophosphamide. ʻO nā kumu hope loa o ka noiʻi ʻana i ka loiloi ʻana i ka helu pane holoʻokoʻa, ka hoʻomau ʻana o ka cell CAR-T, ka hoʻokuʻu cytokine, a me ka nānā ʻana i nā hanana ʻino.
(Hōʻike ke kiʻi i ka hoʻōla ʻana o nā maʻi NHL a me B-ALL)
ʻO ka mea kupaianaha, 11 o nā maʻi 12 i loaʻa i ke kala piha, me ka ʻike ʻia ʻana o ka hoʻonui ʻana o IM19 i ko lākou kahe koko. Ua hoʻonui ka lāʻau lapaʻau i ka hoʻonui ʻana i nā cytokines e like me interleukin-6 a me interleukin-10, e hōʻike ana i kahi pane kūlohelohe ikaika. ʻO ka mea nui, ʻaʻohe o nā mea maʻi i ʻike i ka maʻi hoʻokuʻu cytokine koʻikoʻi a i ʻole CAR-T cell-related encephalopathy, e hōʻike ana i ka ʻike palekana maikaʻi o ka therapy.
Ua mālama ʻia ka noiʻi e kahi hui hui mai ka Halemai maʻi maʻi maʻi ʻo Peking University, Hebei Yanda Lu Daopei Hospital, a me Beijing Immunochina Pharmaceuticals. ʻO Kauka Ying, ka mea kākau alakaʻi, he loea i ka ʻike a me ka mālama ʻana i nā lymphoma malignant, ʻoiai ʻo Kauka Jun Zhu, ka mea kākau pili, he loea kaulana i ka hana like. Ua kākoʻo ʻia kēia haʻawina e kekahi mau haʻawina hanohano, me ka National Natural Science Foundation o Kina a me ka Beijing Natural Science Foundation.
Hāʻawi kēia haʻawina haʻahaʻa honua i nā hōʻike koʻikoʻi ʻaʻole maikaʻi wale ka lāʻau IM19 CAR-T akā palekana no nā poʻe maʻi me nā maʻi maʻi B-cell paʻakikī. Hāʻawi ia i ke ala no ka noiʻi e hiki mai ana a me nā noi lapaʻau e hiki mai ana, e hāʻawi ana i ka manaolana hou i nā poʻe maʻi me nā koho lapaʻau liʻiliʻi.